Author/Editor		Dvoršak, Benjamin; Hojs, Radovan
Title		Hiperhomocisteinemija pri hemodializnih bolnikih
Translated title		Hyperhomocysteinemia in hemodialysis patients
Type		članek
Source		In: Pečovnik-Balon B, editor. Zbornik predavanj Strokovni simpozij z mednarodno udeležbo ob 30. obletnici Oddelka za dializo Splošne bolnišnice Maribor; 2004 feb 6-7; Maribor. Maribor: Splošna bolnišnica Maribor,
Publication year		2004
Volume		str. 45-54
Language		slo
Abstract		Background. Cardiovascular disease is major cause of morbidity and mortality in hemodialysis patients. Hyperhomocysteinemia is now recognised as an independent risk factor for cardiovascular disease. It was reported that plasma homocysteine levels are markedly elevated in hemodialysis patients, hyperhomocysteinemia was found in 75% to 85% of those patients. The aim of the study was to assess the prevalence of hyperhomocysteinemia and to assess possible correlations between serum homocysteine concentrations and serum folic acid and vitamin BlZ concentrations in patients treated in our dialysis unit. Methods. A total of 81 patients (34 woman and 47 men) with end-stage renal disease treated with hemodialysis were included in the study. Mean age was 51,3 years and mean duration of dialysis treatment was 54,7 months. We determined serum concentrations of total homocysteine, folic acid and vitamin Bl2 (immunoassay, Abbott) in our patients. Results. Mean serum homocysteine concentration was 38,9 `mol/I ± 19,4. There were no significant differences found between sexes regarding serum homocysteine concentrations. Hyperhomocysteinemia was present in 96,3 % of patients. Mean serum folic acid concentration was 3,8 nmol/I ± 1,7 and mean serum vitamin BlZ concentration 415,1 pmol/I ± 192,2. We found reduced serum folic acid and vitamin Blz concentrations in 23,8% and 1,3% of patients respectively. There was a significant negative correlation between serum homocysteine concentrations and serum folic acid concentrations (p<0,001) and between serum homocysteine concentraions and serum vitamin B12 concentraions (p<0,002). Conclusions. Hyperhomocysteinemia was common in our dialysis patients and serum homocysteine concentrations were associated with serum folic acid concentrations and serum vitamin B12 concentrations.
Descriptors		KIDNEY FAILURE, CHRONIC HEMODIALYSIS HOMOCYSTEINE FOLIC ACID VITAMIN B 12