Author/Editor		Čerček, Miha
Title		Raznolikost dednega zapisa v genu IL-6 pri bolnikih s koronarno boleznijo
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		2003
Volume		str. 30
Language		slo
Abstract		Background. Inflammation plays a key role in atherosclerotic process. Several atherogenic effects of different cytokines have been described. Recently research focused also on genes coding for cytokines. Certain genetic polymorphisms, including the -174G/C polymorphism of the interleukin 6 gene, are candidates for affecting the risk of coronary heart disease. A few studies examined the association of the -174G/C polymorphism with susceptibility to myocardial infarction but the results were controversial. It is also not clear whether the -174G/C polymorphism is associated with an earlier presentation of coronary heart disease. Aims. We examined the effect of the -174G/C polymorphism in the interleukin 6 gene on risk of developing acute coronary syndrome in a group of Slovenian individuals. We were especially studying the possibility of an association of the -174G/C polymorphism with an earlier development of the disease. Methods. We examined 198 subjects, 121 patients who suffered from an acute coronary syndrome and 77 age and sex matched healthy individuals. In all subjects we studied the polymorphic variation at the promoter region of the interleukin 6 gene and compared the results among different study groups. Separately we made the comparisons also among subgroups of individuals younger than 55 years. Results. The C allele frequency was higher in the study than in the control group (42% vs. 31%; 95% CI). Individuals carrying the C allele had an estimated relative risk of developing acute coronary syndrome of 3,0 (95% CI 1,05-3,40; p<0,05). We observed no significant differences regarding the genotype distribution among subgroups of patients younger than 55 years. Conclusions. Our data confirm the role of the -174G/C polymorphism in the development of the acute coronary syndrome. The presence of the C allele represents an independent factor of coronary heart disease risk. (Abstract truncated at 2000 characters).
Descriptors		CORONARY DISEASE INTERLEUKIN-6 POLYMORPHISM (GENETICS) PROMOTER REGIONS (GENETICS) CORONARY ARTERIOSCLEROSIS POLYMERASE CHAIN REACTION DNA FRAGMENTATION MYOCARDIAL INFARCTION ANGINA, UNSTABLE CREATINE KINASE CREATINE KINASE ISOENZYMES TROPONIN CORONARY ANGIOGRAPHY HYPERTENSION HYPERLIPIDEMIA SMOKING DIABETES MELLITUS