Author/Editor		Urlep-Šalinović, V; Jelatancev, B
Title		Postoperativna tromboprofilaksa pri ortopedskih bolnikih
Translated title		Postoperative thromboprophylaxis in orthopaedic patients
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 61, št. 5-6
Publication year		1992
Volume		str. 275-9
Language		slo
Abstract		Background. Thromboembolisms are impor tant factors in morbidity and mortality of patients subjected to larger orthopaedic operations, however they can be reduced by two thirds with appropriate medicamental and physical prorection. In our study the effectiveness of heparin, heparin dihydergot and ethylbiscoumacetate in the prevention of postoperative throm boembolisms was assessed. Methods. A prospective study involving 421 high risk orthopaedic patients was carried out in order to compare the effectiveness of low dose heparin (SOOOIU Na heparin and 0.5 mg dihydroergotamine mesylate twice daily subcutaneously) and ethylbiscoumacetate (initial dose 150 - 300 mg twelve hours before surgery). All three groups of patienis were well matched for age, sex, type of disease, duration of operation as well as incidence of risk factors which predispose the development of thromboembolism. Results. The clinical thromboembolism, confirmed by radioisotopic phlebography and lung perfusion scanning group, was demonstrated in 11 patients (10.4 per cent ) of low dose heparin, in 7 patients (5.9 per cent ) of the heparin dihydergot group and in 3 patients (1.5 per cent ) of the ethylbiscoumacetate group. Ethylbis coumacetate was significantly superior to low dose heparin (p less th. 0.001) and heparin dihydergot (p less th. 0.02) treatments. Adverse drug effects did nor differ significantly among the groups and consisted of postoperative bleeding in 7 patients (6.6 per cent ) in the low dose heparin group, in 8 patients (7 per cent ) in the heparin dihy group. dergot group and in 10 patients (5 per cent ) in the ethylbiscoumacetate Results. Thromboprophylaxis in orthopaedic and traumarologic surgery patients is indispensable and should be spe cially adapted to each particular patient.(trunc.)
Descriptors		THROMBOEMBOLISM POSTOPERATIVE CARE HEPARIN ETHYL BISCOUMACETATE PROSPECTIVE STUDIES ADULT DIHYDROERGOTAMINE HIP PROSTHESIS KNEE PROSTHESIS FRACTURE FIXATION, INTERNAL RISK FACTORS