Author/Editor		Pavčnik, Maja; Kovačič, Uroš
Title		Sproženje kolateralnega brstenja senzoričnih aksonov pri podgani
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		1997
Volume		str. 39
Language		slo
Abstract		Background. Collateral sprouting of axons in the peripheral nervous system is a branching outgrowth of new axon terminals from noninjured axons into adjacent denervated regions of a target tissue. Initiation of collateral sprouting is probably triggered by an interaction between the factors released by degenerated neural pathways or denervated target tissue, and putative transneuronal mechanisms. Objective. We will investigate the following hypotheses: a) the presence of degenerated neural pathways is not sufficient to induce collateral sprouting. Denervated target tissue or transneuronal mechanisms are necessary for induction of sprouting; b) interaction between the injured and non-injured neurons within a dorsal root ganglion (transneuronal mechanism) is an important stimulus for initiation of collateral sprouting, c) the sprouts arise only from parts of axons adjacent to denervated perineurial sheats. Methods. Experiments were preformed on the hind limb of the rat. Sprouting of axons along the neurilemmal tubes of Schwann cells was investigated by an end-to-side anastomosis of a peroneal nerve segment to the intact sural nerve. In group A the peroneal nerve segment from the contralateral limb was attached to the sural nerve. None of the nerves on the side of anastomosis were injured. In group B the same procedure was made as in group A. In addition, dorsal-cutaneous nerves (DCN) from spinal segments L4-L6 were cut. Injured neurons were therefore present in the dorsal root ganglia from which axons of the sural nerve arise. The skin of the limb was not denervated. In group C an end-to-side anastomosis of the peroneal nerve segment from ipsilateral limb was made on the sural nerve. On the same limb, saphenus nerve was cut and ligated. The skin around the terminal innervation field of the sural nerve was therefore denervated. (Abstract truncated at 2000 characters)
Descriptors		SURAL NERVE PERONEAL NERVE ANASTOMOSIS, SURGICAL HINDLIMB AXONS RATS, WISTAR IMAGE PROCESSING, COMPUTER-ASSISTED