Author/Editor		Faganel, Barbara; Černelč, Peter
Title		Pojav protiteles za faktor VIII pri starejšem bolniku z lahko obliko hemofilije A
Translated title		The appearance of the inhibitors to factor VIII in an elder patient with mild haemophilia A
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 73, št. Suppl 1
Publication year		2004
Volume		str. I-163-4
Language		slo
Abstract		Background. The inhibitors to F Vlll are unusual in case of a mild haemophilia because the replacement therapy is seldom necessary. In case of severe trauma, when prolonged replacement therapy of F VIII is needed, the appearance of the inhibitors is more frequent The mild form of the disease becomes a severe one and the haemorrhages are frequent. Patient and methods. In case of outpatient with mild form of haemophilia, the inhibitors to F VIII developed after prolonged replacement therapy for treatment of subdural haemorrhage. In the article we describe recurrent haemorrhages and treatement of them with FEIBA and rF Vlla. Conclusions. Due to poor compliance of an elder patient we didn't decide to treat the inhibitors for F VIII actively.
Summary		Izhodišča. Protitelesa za F Vlll se pri bolniku z lahko obliko hemofilije zelo redko pojavijo, saj je nadomestno zdravljenje s F Vlll običajno le redko potrebno. V primeru hujše poškodbe, ko je potrebno dolgotrajnejše zdravljenje s F Vlll, pa se protitelesa lahko pojavijo. Tako lahka oblika bolezni postane težka in poteka s ponavljajočimi se krvavitvami. Bolniki in metode. Pri našem bolniku z lahko obliko bolezni so se protitelesa za F VIII pojavila po daljšem nadomestnem zdravljenju subduralne krvavitve. Opisujemo ponavljajoče se krvavitve in zdravljenje teh s FEIBO in rF Vlla. Zaključki. Za aktivno zdravljenje protiteles za FVIll se zaradi slabšega sodelovanja starejšega bolnika nismo odločili.
Descriptors		HEMOPHILIA FACTOR VIII AUTOANTIBODIES SUBARACHNOID HEMORRHAGE AGED