Author/Editor		Kolman, Jana; Gubina, Marija
Title		Trendi občutljivosti invazivnih izolatov bakerije Staphylococcus aureus v Sloveniji in Evropi - rezultati projekta EARSS
Translated title		Trends in antimicrobial susceptibility of invasive isolates of Staphylococcus aureus in Slovenia and Europe - results of EARSS project
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 43, št. Suppl 2
Publication year		2004
Volume		str. 11-7
Language		slo
Abstract		Methicillin resistant Staphylococcus aureus (MRSA) is an important cause of hospital acquired infections. Results of three years follow-up of antibiotic susceptibility of invasive isolates of S. aureus and MRSA from blood cultures of patient s in Slovenia during European Antimicrobial Resistance Surveillance System (EARSS) project are presented. From the year 2002 with the involvement of the one more microbiology laboratory, estimated catchment's population for Slovenia was almost 100%. From the 2nd half of 2000 to the 1st half of 2003, MRSA were reported in 141 (17%) out of 830 first blood culture isolates of S. aureus per patient per year. Decrease of MRSA from 21.4% in the year 2000 to 13.1% in the first half of 2003 was observed. Slovenia was the only country with consistent decrease in MRSA among other countries participating in EARSS and as such reported for at least three consecutive years. MRSA isolates were more frequent among males - 19% (in 91 out of 492), than females - 15% (in 50 out of 339). The highest proportion of MRSA (21%) was observed in patients older than 65 years. In ten hospitals the proportions of MRSA were from 9% to 33%. MRSA isolates were mainly multiresistant - besides oxacillin the resistance to gentamycin, ciprofloxacin, erythromycin and clindamycin were noticed. With 13.8% MRSA and estimated incidence rate of nosocomial bloodstream infections per 100.000 patients days in 2002 Slovenia took place in the lower third amongs countries participating in EARSS project.
Summary		Proti meticilinu odporna bakterija Staphylococcus aureus (MRSA) je pomemben povzročitelj bolnišničnih okužb. V prispevku prikazujemo rezultate triletnega spremljanja občutljivosti invazivnih izolatov S. aureus in MRSA iz krvi bolnikov v Sloveniji v okviru projekta EARSS (angl. European Antimicrobial Resistance Surveillance System). Od leta 2002 je bilo z vključitvijo še enega mikrobiološkega laboratorija zagotovljeno zajemanje praktično vseh bolnikov s temi izolati v Sloveniji. V obdobju od 2. polovice 2000 do 1. polovice 2003 smo od skupno 830 prvih izolatov S. aureus iz krvi na bolnika na koledarsko leto osamili MRSA v 141 (17%) primerih. Delež MRSA se je vztrajno zniževal od 21,4% v letu 2000 do 13,1% v prvi polovici leta 2003. Med državami, ki so vključene v projekt EARSS, je bila Slovenija edina s statistično značilnim padanjem deleža MRSA v vsaj treh zaporednih letih. Pri moških je bilo 19% (91 od 491) bolnikov z MRSA, pri ženskah 15% (50 od 339). Najvišji, 21-odstotni, delež bolnikov z MRSA je bil v starostni skupini nad 65 let. V desetih bolnišnicah, kjer so se zdravili bolniki z okužbami krvi z MRSA, so znašali deleži MRSA med vsemi okužbami krvi s S. aureus od 9% do 33%. Sevi MRSA so bili praviloma odporni proti oksacilinu, poleg tega pa še proti gentamicinu, ciprofloksacinu, eritromicinu in klindamicinu. Slovenija se je s podatki za leto 2002 s 13,8-odstotnim deležem MRSA in z oceno pojavne stopnje 1,8 okužbe krvi z MRSA na 100.000 bolnišnično oskrbnih dni uvrstila v spodnjo tretjino med državami, ki so vključene v projekt EARSS.
Descriptors		STAPHYLOCOCCUS AUREUS METHICILLIN RESISTANCE DRUG RESISTANCE, MICROBIAL ANTIBIOTICS SEX FACTORS SLOVENIA EUROPEAN ECONOMIC COMMUNITY