Author/Editor		Beović, Bojana; Lejko-Zupanc, Tatjana
Title		Novosti v zdravljenju glivičnih okužb
Translated title		New treatment options for fungal infections
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 43, št. Suppl 2
Publication year		2004
Volume		str. 83-96
Language		slo
Abstract		Serious underlying diseases, demanding diagnostics and poor choice of antifungal drugs make treatment of invasive fungal infections very difficult. Recently, the choice of antifungal drugs was enlarged by lipid forms of amphotericin B, azole voriconazole and the first clinically used echinocandin caspofungin. Lipid formulations of amphotericin B proved to be at least as effective and certainly safer than conventional amphotericin B. Voriconazole and caspofungin proved their safety as well. Clinical studies established voriconazol as an important drug for treatment of invasive aspergillosis. Caspofungin is especially effective against Candida including non-albicans Candida species. Caspofungin was also effective in several patients who failed previous treatment of invasive aspergillosis.
Summary		Zdravljenje sistemskih glivičnih okužb je težavno zaradi hudih osnovnih bolezni bolnikov, zahtevne diagnostike in skope izbire protiglivičnih zdravil. V zadnjem času so se na tržišču pojavili nekateri novi antimikotiki, lipidne oblike amfotericina B, azolni antimikotik vorikonazol in prvi ehinokandinski antimikotik kaspofungin. Lipidne oblike amfotericina B so vsaj tako uspešne kot osnovna različica zdravila in gotovo varnejše. Tudi vorikonazol in kaspofungin sta po dosedaj znanih podatkih varni zdravili. Vorikonazol se je uveljavil predvsem kot učinkovito zdravilo za invazivno aspergilozo. Kaspofungin odlikuje njegova učinkovitost proti kandidi, posebej pomembna je učinkovitost proti vrstam rodu kandide, ki so odporne na azolne antimikotike. Učinkovit je tudi pri nekaterih bolnikih z invazivno aspergilozo, pri katerih druge oblike zdravljenja niso bile uspešne.
Descriptors		MYCOSES ANTIFUNGAL AGENTS TRIAZOLES FLUCONAZOLE AMPHOTERICIN B