Author/Editor		Trihia, Helen; Murray, Susan; Price, Karen; Gelber, Richard D; Golouh, Rastko; Goldhirsch, Aron; Coates, Alan S; Collins, John; Castiglione-Gertsch, Monica; Gusterson, Barry A
Title		Ki-67 expression in breast carcinoma: its association with grading systems, clinical parameters, and other prognostic factors - a surrogate marker?
Type		članek
Source		Cancer
Vol. and No.		Letnik 97, št. 5
Publication year		2003
Volume		str. 1321-31
Language		eng
Abstract		Background. The number of mitoses and, thus, the proliferative capacity of a tumor is one of the most crucial variables for turnor grading. The Ki-67 nuclear antigen may be considered as an alternative to mitotic counts in grading schemes and as a single parameter that can be used in fine-needle aspirates and small biopsies. Methods. Immunohistochemistry using the anti-Ki-67 antibody MIB-1 was performed on 434 breast carcinoma specimens from the Intemational Breast Cancer Study Group (formerly Ludwig) Trial V. Three groups based on Ki-67 percent were used to replace the mitotic counts component in the Nottingham grade (NHG) to produce the Nottingham/Ki-67 grade (NKG) and to assess Ki-67 as a single parameter. Results. In both the lymph node positive subgroup and the lymph node negative subgroup, the NKG and Ki-67 group was correlated significantly with BloomRichardson grade (BRG), NHG, and Nottingham type. Tumor size in the lymph node negative cohort and estrogen receptor status, progesterone receptor status, and c-erbB-2 expression in the lymph node positive cohort also were correlated significantly with NKG. Ki-67 percentage was correlated significantly with c-erbB-2 expression in the lymph node positive cohort only. NKG was similar to BRG and NHG when it was evaluated for prognostic significance. Patients with higher categoric Ki-67 percentages had wors2 overall and disease free survival in all groups except for the untreated, lymph node negative group. Conclusions. Ki-67 detection represents a valuable tool and is a good objective substitute for mitotic counts when used in a grading system. When it is used alone, Ki-67 detection provides valuable information, although it is necessary to combine this with other parameters in the study of core biopsies and fine-needle aspirates.
Descriptors		BREAST NEOPLASMS KI-67 ANTIGEN DISEASE-FREE SURVIVAL IMMUNOHISTOCHEMISTRY MULTIVARIATE ANALYSIS PROGNOSIS RANDOMIZED CONTROLLED TRIALS