Author/Editor		Gašljević, Gorana; Lamovec, Janez
Title		Malignant lymphoma of the stomach in association with inflammatory myofibroblastic tumor of the spleen. A case report
Type		članek
Source		Pathol Res Pract
Vol. and No.		Letnik 199, št. 11
Publication year		2003
Volume		str. 745-9
Language		eng
Abstract		We report on a case of a 40-year-old male patient who underwent a gastrectomy because of a biopsy-proven large B-cell lymphoma of the stomach. On surgery, a nodule in the spleen also was noted. Grossly and microscopically, the two lesions were different: the tumor of the stomach appeared white-gray on the cut surface and was a centroblastic variant of diffuse large B-cell lymphoma. Histologically, one perigastric lymph node was involved. Grossly, the splenic nodule was gray-yellow and had a histological appearance of an inflammatory myofibroblastic tumor (IMT). The association between malignant tumor and IMT is rare. In such an association, the latter lesion most often has been reported in the spleen. As EBV may be involved in the genesis of both lymphoma and IMT, we tested both lesions for its presence using in situ hybridisation, but the tests were negative. It remains to be verified whether the association between lymphoma and IMT is more than fortuitous.
Descriptors		STOMACH NEOPLASMS LYMPHOMA, B-CELL SPLENIC NEOPLASMS NEOPLASMS, MUSCLE TISSUE ADULT HERPESVIRUS 4, HUMAN IN SITU HYBRIDIZATION IMMUNOHISTOCHEMISTRY