Author/Editor		Smits, Kim M; Benhamou, Simone; Garte, Seymour; Weijenberg, Matty P; Alamanos, Yannis; Ambrosone, Christine; Autrup, Herman; Autrup, Judith L; Baranova, Helena; Dolžan, Vita
Title		Association on metabolic gene polymorphisms with tobacco consumption in healthy controls
Type		članek
Source		Int J Cancer
Vol. and No.		Letnik 110
Publication year		2004
Volume		str. 266-70
Language		eng
Abstract		Polymorphisms in genes that encode for metabolic enrymes have been associated with variations in enryme activity between individuals. Such variations could be associated with differences in individual exposure to carcinogens that are metabolized by these genes. In this study, we examine the association between polymorphisms in several metabolic genes and the consumption of tobacco in a large sample of healthy individuals. The database of the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens was used. All the individuals who were controls from the case-control studies included in the data set with information on smoking habits and on genetic polymorphisms were selected (n = 20,938). Sufficient information was available on the following genes that are invohed in the metabolism of tobacco smoke constituents: CYP1A1, GSTM1, GSTT1, NAT2 and GSTP1. None of the tested genes was clearly associated with smoking behavior. information on smoking dose, available for a subset of subjects, showed no etfect of metabolic gene polymorphisms on the amount of smoking. No association between polymorphisms in the genes studied and tobacco consumption was observed; therefore, no effect of these genes on smoking 6ehavior should 6e expected.
Descriptors		SMOKING POLYMORPHISM (GENETICS) CYTOCHROME P-450 CYP1A1 GLUTATHIONE TRANSFERASES GENOTYPE POLYMERASE CHAIN REACTION CASE-CONTROL STUDIES