Author/Editor		Markovič, Saša
Title		Patogeneza portalne hipertenzije
Translated title		Pathogenesis of portal hypertension
Type		članek
Source		Gastroenterolog
Vol. and No.		Letnik 8, št. 1-2
Publication year		2004
Volume		str. 29-33
Language		slo
Abstract		Portal hypertension is defined as elevation in portal pressure as the result of increased vascular resistance in the liver and increased portal blood flow due to hyperdynamic circulation. In 90% of patients, liver cirrhosis is responsible for portal hypertension. In sinusoidal hypertension, the major role in increased vascular resistance depends on mechanical and functional factors. Hemodynamic changes are characterized by systemic and splanhnic hyperdynamic circulation. The venous collaterals are opened when the portal pressure exceeds 12 mmHg. The number of factors involved in portal hypertension are responsive to pharmacotherapy.
Summary		Portalna hipertenzija označuje trajno zvišanje pritiska v portalni veni in je posledica zvišanega odpora v jetrih in povečanega pretoka v portalni veni zaradi hiperdinamičnega sistemskega krvnega obtoka. V 90% je vzrok portalni hipertenziji jetrna ciroza in portalna hipertenzija je sinusoidalna. Poglavitno vlogo v zvišanju odpora v jetrih igrajo poleg mehanskih tudi funkcionalni dejavniki. Hemodinamske spremembe so posledica hiperdinamične sistemske in splanhnikove cirkulacije. Kolateralni obtok in krvavitev iz varic je posledica dviga portalenga tlaka nad 12 mmHg. Na številne dejavnike, ki zvišujejo portalni tlak lahko vplivamo z zdravili.
Descriptors		HYPERTENSION, PORTAL