Author/Editor		Kovačič, Dragan; Marinšek, Matej; Voga, Gorazd; Vodopivc, Darja; Podbregar, Matej
Title		Kakovost življenja bolnikov po masivni pljučni emboliji
Translated title		Quality of life in patients after massive pulmonary embolism
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 73, št. 4
Publication year		2004
Volume		str. 213-8
Language		slo
Abstract		Background. Pulmonary embolism is a disease, which has a 30% mortality if untreated, while an early diagnosis and treatment lowers it to 2-8%. Health related quality of life (HRQL) of patients who survived massive pulmonary embolism is unknown in published literature. In our research we tried to apply experience of foreign experts in estimation of quality of life in some other diseases to the field of massive pulmonary embolism. Patients and methods. Eighteen patient with shock or hypotension due to massive pulmonary embolism, treated with thrombolysis, between July 1993 and November 2000, were prospectively included in the study. Control group included 18 gender and age matched persons. There were no significant differences regarding demographic data between the groups. The HRQL and aerobic capacity of patients and control group were tested with short questions and questionnaires (Veterans brief, self administered questionnaire (VSAQ), EuroQuality questionnaire (EQ), Living with heart failure questionnaire (LIhHF). With LlhHF physical (F-LIhHF) and emotional (E-LlhHF) HRQL was assessed at hospitalization and 12 months later. Results. One year after massive pulmonary embolism aerobic capacity (-9.5%, p < 0.017) and HRQL (EQ (-34.5%), F-LLIaHF (-85.4%), E-LIhHF (-48.7%)) decreased in massive pulmonary embolism group compared to aerobic capacity 6 months before massive pulmonary embolism and HRQL. Heart rate before thrombolysis correlated with aerobic capacity (r = 0.627, p < 0.01), EQ (r = 0.479, p < 0.01) and F-LIhHF (r = 0.479, p = 0.04) 1 year after- massive pulmonary embolism. Total pulmonary resistance at 12 hours after start of treatment correlated with aerobic capacity at 1 year (r = 0.354, p < 0. 01). (Abstract truncated at 2000 characters).
Summary		Izhodišča. Pljučna embolija je bolezen, pri kateri je brez zdravljenja smrtnost 30-odstotna, zgodnja pravilna diagnoza in zdravljenje smrtnost znižata na 2-8%. Podatkov o z zdravjem povezani kakovosti življenja bolnikov po preboleli masivni pljučni emboliji (health related quality of life; HRQL) v objavljeni literaturi ni. Zato smo v svoji raziskavi skušali uporabiti izkušnje tujih strokovnjakov iz ocenjevanja kakovosti življenja pri nekaterih drugih boleznih. Metode. V prospektivno nerandomizirano raziskavo smo vključili osemnajst bolnikov s šokom ali hipotenzijo zaradi masivne pljučne embolije, ki so bili zdravljeni s trombolizo na Oddelku za intenzivno interno medicino SB Celje od julija 1993 do novembra 2000. V raziskavo je bila vključena še kontrolna skupina osemnajstih zdravih ljudi, po starosti in spolu enakih bolnikom. Skupini se nista razlikovali po demografskih podatkih. Bolniki so med rednim ambulantnim pregledom izpolnjevali več vprašalnikov za ugotavljanje HRQL 6 mesecev pred prebolelo masivno pljučno embolijo in 12 mesecev po njej (metoda enostavnih vprašanj; vprašalnik, za ugotavljanje telesne aerobne zmogljivosti - Veterans brief, self administered questionnaire (VSAQ); evropski vprašalnik za ugotavljanje kakovosti življenja - EuroQuality questionnaire (EQ); vprašalnik o življenju s srčnim popuščanjem - Livirag with heart failure questionnaire, (LIhHF); slednji ima dve podenoti; F-LIhHF in E-LIhHF za ločeno ugotavljanje fizične in emocionalne kakovosti življenja). Rezultati. Aerobna zmogljivost se je v skupini z masivno pljučno embolijo v letu dni po emboliji glede na stanje 6 mesecev pred njo zmanjšala (-9,5%, p < 0, 017). Bolnikom se je 12 mesecev po preboleli masivni pljučni emboliji poslabšala tudi kakovost življenja, ocenjena zEQ (-34,5%), s F-LIhHF(-85, 4%) in E-LIhHF (-48,7%) vprašalnikom. (Izvleček skrajšan pri 2000 znakih).
Descriptors		PULMONARY EMBOLISM QUALITY OF LIFE ACTIVITIES OF DAILY LIVING QUESTIONNAIRES BLOOD PRESSURE HEART RATE CATHETERIZATION, CENTRAL VENOUS PROSPECTIVE STUDIES