Author/Editor     Lešničar, Gorazd; Gabršček, Lucija; Krivec, Bojan; Voga, Gorazd; Šibanc, Branko; Blatnik, Janja; Jagodič, Boris
Title     Večorganska odpoved po naključni zastrupitvi z jesenskim podleskom
Translated title     Multiorgan injury after accidental poisoning with autumn crocus
Type     članek
Source     Zdrav Vestn
Vol. and No.     Letnik 73, št. 4
Publication year     2004
Volume     str. 219-22
Language     slo
Abstract     Background. A case of accidental poisoning with autumn crocus (Colchicum autumnale) that was misinterpreted for wild garlic (Allium ursinum) is presented. Both plants grow on damp meadows and can be easily wrongly identified especially before blooming period as they have similar, pointed leaves. Results. Considering anamnestic data, clinical picture and laboratory findings in 43 yr-old female, a poisoning with the colchicine plant alkaloid was suspected. Later, it was confirmed by toxicology analyses (chromatography and spectrometry) of the collected serum and urine samples. Severe initial gastrointestinal disorders progressed into ileus, bone-marrow suppression and multi-organ failure. Conclusions. After the patient had received a symptomatic treatment with granulocyte-directed growth factor and a suitable antibiotic therapy for secondary infection, she recovered within three weeks from the onset of condition. The most persistent problem was alopecia. The disease did not entailed any permanent sequellae which was confirmed 3 years after the patient was considered cured.
Summary     Izhodišča. Opisan je primer naključne zastrupitve z jesenskim podleskom (Colchicum autumnale), ki je nastala zaradi zamenjave z divjim česnom, bolje poznanim kot čemaž (Allium ursinum). Obe rastlini rasteta na vlažnih travnikih in imata zelo podobne suličaste liste. Zamenjamo ju lahko zlasti spomladi, ko še nimata cvetov. Rezultati. Po anamnestičnih podatkih, klinični sliki in laboratorijskih izvidih smo posumili pri 43-letni bolnici na zastrupitev z rastinskim alkaloidom - kolhicinom, kar je bilo kasneje potrjeno z izvidi toksikološke analize (kromatografsko in spektrometrično) odvzetih vzorcev seruma in urina. Hude začetne prebavne težave so napredovale v ileus, zavrtje delovanja kostnega mozga in večorgansko odpovedovanje. Zaključki. Bolnica je po hudi zastrupitvi z večorgansko odpovedjo prej kot v treh tednih ob simptomatskem zdravlenju z rastnim faktorjem granulocitne vrste in ustreznem antibiotičnem zdravljenju sekundarne okužbe okrevala. Najdlje je vztrajala alopecija. Bolezen ni zapustila posledic, kar smo preverili tri leta po prestani bolezni.
Descriptors     COLCHICUM
COLCHICINE
MULTIPLE ORGAN FAILURE
ADULT