| Author/Editor | Petrovič, Danijel; Peterlin, Borut | |
| Title | Genetski (DNA) označevalci za koronarno bolezen | |
| Type | članek | |
| Source | Slov Kardiol | |
| Vol. and No. | Letnik 1, št. 1 | |
| Publication year | 2004 | |
| Volume | str. 26-9 | |
| Language | slo | |
| Abstract | Coronary artery disease is multifactorial disorder. There are several gene markers for CAD, existing either at the level of proteins (i.e. C-reactive protein, interleukin 6), DNA (different genetic polymorphisms) or mRNA. With these markers we can predict CAD and its complications (acute coronary syndrome, sudden cardiac death), and also restenosis after percutaneous coronary angioplasty or stenting. Biological approach is used for testing of new gene polymorphisms (potential genetic risk factors). Moreover, we should emphasize the importance of gene-environment interaction at both personal and population level, the field covered by pharmacogenomics. The knowledge of genetic markers at individiual and/or population level could serve as a part of the global cardiovascular assessment. | |
| Summary | Koronarna bolezen je multifaktorsko pogojena genetska bolezen. Poznamo številne označevalce (markerje) za koronarno bolezen, ki so lahko na ravni beljakovin (npr. C-reaktivna beljakovina, interlevkin 6), na ravni DNA (različni genetski polimorfizmi) in na ravni mRNA. S temi označevalci (beljakovine, mRNA, DNA) lahko napovemo koronarno bolezen in njene zaplete (akutni koronarni sindrom, nenadno srčno smrt) ter morebitne zaplete po perkutani koronarni angioplastiki in vstavitvi žilne oporonice. Pri testiranju oziroma izbiranju novih genetskih polimorfizmov (potencialnih genetskih dejavnikov tveganja) največkrat uporabljamo biološki pristop, kar pomeni, da izhajamo iz poznavanja patogenetskega procesa aterotromboze. Poudariti moramo tudi pomen medsebojnega delovanja genetskih dejavnikov (genetski polimorfizmi) in dejavnikov okolja (npr. učinek zdravil) na ravni posameznika in populacije, s čimer se ukvarja farmakogenomika. Poznavanje genetskih označevalcev na ravni posameznika in populacije je del celovite ocene srčno-žilne ogroženosti. | |
| Descriptors | CORONARY DISEASE POLYMORPHISM (GENETICS) GENETIC MARKERS ANGIOPLASTY, TRANSLUMINAL, PERCUTANEOUS CORONARY STENTS CONSTRICTION, PATHOLOGIC |