Author/Editor		Rogač, Mihael
Title		Nepravilnosti korpusa kalozuma pri otrocih
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		2004
Volume		str. 40
Language		slo
Abstract		The corpus callosum is the main commissural bundle of fibers interconnecting the two cerebral hemispheres in the human brain. The corpus callosum dysgenesis comprises several degrees of improper neurodevelopment of the corpus callosum, from agenesis, hypogenesis to hypoplasia of the corpus callosum. This study reports on the prevalence of the corpus callosum dysgenesis in Slovenia, the clinical profile, neurophysiological and neuroradiological characteristics. The study aims to find differences in the clinical profile of agenesis and hypoplasia of the corpus callosum. The possibility of acquired dysgenesis of the corpus callosum was considered. 58 children with the corpus callosum dysgenesis were identified in the period from 1998 to 2003 by magnetic resonance imaging, while 45 children and their parents responded to our invitation: 16 with agenesis, 5 with hypogenesis and 24 with hypoplasia of the corpus callosum. A clinical neurological examination and neurodevelopmental testing were performed for each child and a questionnaire about pregnancy risk factors and child's medical history was completed by a parent. The prevalence of diagnosed corpus callosum dysgenesis in Slovenia is 4-9 children per 10,000 newboms. The number of cases varies from year to year, however, based on Slovenia's birthrate in recent years 3-8 children per year were bom with agenesis of the corpus callosum and 3-13 children per year with hypoplasia of the corpus callosum. Seventeen children of 45 included (40%) were microcephalic, 22 (49%) were dysmorphic, 14 (30%) were hypotonic, 22 (50%) were hypertonic and 26 (58%) had a cerebral palsy. Study identified severe developmental delay in 34 children (75%). 20 (45%) had coexisting epilepsy, 8 (18%) had congenital heart disease and 6 (13%) had congenital anomalies of genitourinary tract. (Abstract truncated at 2000 characters).
Descriptors		CORPUS CALLOSUM DEVELOPMENTAL DISABILITIES NEUROLOGIC EXAMINATION PSYCHOLOGICAL TESTS CHILD APGAR SCORE INFANT, NEWBORN, DISEASES AGE FACTORS MAGNETIC RESONANCE IMAGING ELECTROENCEPHALOGRAPHY QUESTIONNAIRES BIRTH WEIGHT PREGNANCY COMPLICATIONS CEPHALOMETRY EPILEPSY