Author/Editor		Štabuc-Šilih, Mirna
Title		Klinične in genetske značilnosti keratokonusa
Type		monografija
Place		Ljubljana
Publisher		Univerza v Ljubljani, Medicinska fakulteta
Publication year		2004
Volume		str. 126
Language		slo
Abstract		Keratoconus (KC) is a noninflammatory corneal ectasia with an incidence of approximately 50-230 / 100,000 in the general population. The cause of this condition is stifl largely unknown in spite of intensive clinical and laboratory investigations. Although the cause of KC is unknown, there are several lines of evidence suggesting a genetic component. A positive association between KC and many conditions has been suggested, including atopy and eye rubbing. In this study we attempted to study the factors that have been associated with the aetiology of KC, and specially VSX 1: a gene that has been associated with posterior polymorphous dystrophy and KC. The influence of corneal thickness and curvature on the difference between intraocular pressure (IOP) measurements obtained with noncontact (NCT) and those with Goldmann applanation tonometer (GAT) was also studied in patients with KC. As we did not find any reports of visual field in patients with KC, we tested them with Octopus perimeter tG2 Glaucoma program. We also did not notice any published study on quality of life of patients with KC. The subjects of this study were selected from the file of 935 patients with KC in the Eye Clinic of Ljubljana. Each patient's medical records were reviewed to determine the diagnostic and other criteria for inclusion in this study. Finally, 113 patients (226 eyes), 70 male and 43 female met the criteria for inclusion. 37 had a positive family history of KC. We performed the clinical examination of patients. Intraocular pressure (IOP) measurements were obtained with non-contact (NCT) and with Goldmann applanation tonometer (GAT). Topography was performed using a videokeratograph TMS 1Topographic Modeling System (Computed Anatomy, New York) and Orbscan Version 3.0 Bausch & Lomb Surgical. The visual field was recorded using Octopus 101 V 3.16g Interzeag Seven-in-One, program tG2 / 0, strategy TOP I. (Abstract truncated at 2000 characters).
Descriptors		KERATOCONUS INTRAOCULAR PRESSURE VISUAL FIELDS VISUAL ACUITY PERIMETRY TONOMETRY SCOTOMA ASTIGMATISM POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL BASE SEQUENCE POLYMERASE CHAIN REACTION EXONS QUALITY OF LIFE QUESTIONNAIRES