Author/Editor     Evangelista, S; Reanzi, D; Guzzi, P; Maggi, A
Title     Decrease of gastric calcitonin gene-related poptide-like immunoreactivity is associated with locers induced by water-immersion stress in rats
Type     članek
Source     Exp Clin Gastroenterol
Vol. and No.     Letnik 1, št. 1
Publication year     1991
Volume     str. 51-3
Language     eng
Abstract     This study investigated the changes of gastric levels of calcitonin gene-related peptide-like immunoreactivity (CGRP-li) following the induction of gastric ulcers in rats. Gastric CGRP-li is decreased in corupus samples from ulcerated stomachs induced by water-immersion stress (WIS) but not by indomethacin (20 mg/kg s.c.). WIS produced a significant decrease in CGRP-li in the whole thickness of the glandular portion of the stomach and not in its mucosal layers, indicating that the muscular layer of the stomach is the region involved in this phenomenon. Systemic administration of CGRP (25 microgramme/kg s.c.) produced a significant decrease in both length of ulcers and gastric acid secretion induced by WIS. The effect on gastric acid hypersecretion, which plays a pivotal role in WIS ulcers, may contribute to the protective effect of CGRP in WIS ulcers. These findings suggest that WIS inuced a release of CGRP from the sensory nerve endings present in the muscular layers of the stomach and this peptide seems to play a defensive role in WIS-ulcers
Descriptors     GASTRIC MUCOSA
STOMACH ULCER
STRESS
CALCITONIN GENE-RELATED PEPTIDE
IMMERSION
INDOMETHACIN
RATS, INBRED STRAINS
RATS