Author/Editor		Kitajima, M; Nakajima, M; Chiba, A; Tsuji, T; Hayashi, M; Ubukata, N
Title		Experimental and clinical studies on the development of acute gastric mucosal lesions in portal hypertension
Type		članek
Source		Exp Clin Gastroenterol
Vol. and No.		Letnik 1, št. 1
Publication year		1991
Volume		str. 65-71
Language		eng
Abstract		In clinical studies, acute gastric mucosal lesions (AGML) developed in patients with portal lypertension. Based on these clinical observations of AGML, experimental and clinical studies were performed to elucidate the pathogenesis of them in portal hypertension. Portal hypertension was experimentally created by ligation of portal vein in male Wistar rats (N=80). AGML developed at 6 weeks after ligation and esophageal venous dilatations were observed endoscopically at 4 weeks. Portal venous pressure increased significantly until 4 week after ligation (P less than 0.01) and it recovered to normal level at 6 weeks. This reduction of venous pressure was suggested to be a formation of collateral portal circulation. Histopathological findings of stomach demonstrated the icrease of venous pressure as congestion and interstitial edema of the gastric mucosa. On the other hand, gastric mucosal blood flow decreased significantly after ligation compared with normal control. Twenty-six patients with esophageal varices who were operated on by esophageal transection, had an incidence of 57.5 per cent with gastric lesions before operation. Surgical management by esophageal transection and truncal vagotomy with pyloroplasty resulted in a 50 per cent improvement of the gastric lesions. In conclusion, experimental and clinical results suggested that defensive factors of the gastric mucosa might be disrupted in portal hypertension
Descriptors		HYPERTENSION, PORTAL GASTRIC MUCOSA HEMORRHAGE GLUCAGON GASTRINS ESOPHAGEAL AND GASTRIC VARICES RATS, INBRED STRAINS RATS