Author/Editor     Mancini, Ines; Sicurelli, Adriana; Guella, Graziano; Turk, Tom; Maček, Peter; Sepčić, Kristina
Title     Synthesis and bioactivity of linear oligomers related to polymeric alkylpyridinium metabolites from the Mediterranean sponge Reniera sarai
Type     članek
Source     Org Biomol Chem
Vol. and No.     Letnik 2
Publication year     2004
Volume     str. 1368-75
Language     eng
Abstract     Dimers and tetramers of linear 3-alkylpyridinium salts have been synthesized by an efficient synthetic pathway, which is also applicable to the preparation of higher oligomers. Mono-, di- and tetrameric compounds have been tested for antibacterial and hemolytic activities and for the inhibition of acetylcholinesterase and protein phosphatase 2A. Their activities were compared to those of the natural poly-3-octylpyridinium alkaloids isolated from the Mediterranean sponge Reniera sarai. Relatively high antibacterial and anti-acetylcholinesterase activities were observed that increase with higher degrees of oligomerization.
Descriptors     PORIFERA
PYRIDINIUM COMPOUNDS
POLYMERS
BIOLOGICAL ASSAY
BACILLUS SUBTILIS
HEMOLYSIS
CHOLINESTERASE INHIBITORS