| Author/Editor | Grach-Pogrebinsky, Olga; Sedmak, Bojan; Carmeli, Shmuel | |
| Title | Seco(D-Asp3)microcystin-RR and (D-Asp3,D-Glu(OMe)6)microcystin-RR, two new microcystins from a toxic water bloom of the Cyanobacterium Planktothrix rubescens | |
| Type | članek | |
| Source | J Nat Prod | |
| Vol. and No. | Letnik 67 | |
| Publication year | 2004 | |
| Volume | str. 337-42 | |
| Language | eng | |
| Abstract | Two novel rnicrocystins, sero[n-Asp'Jrnicrocystin-RR (1) and [D-AspB,D-Glu(OMe)6-microcystin-RR (2), along with the known [D-Asp3Jmicrocystin-RR (3), were isolated from a Planktothrix rubescens toxic bloom c:ollected in Lake Bled. Slovenia. The struetures were deduced using one- and two-dimensional NMR techniques, ESIMS/CID/MS analysis, and Marfey's method for determining the amino acids' absolute stereochemistry. Compounds 1 and 3 exhibit weak PP1 inhibitory activity. The NMR data of compouncl 3 are reported here For the first time. | |
| Descriptors | CYANOBACTERIA BACTERIAL TOXINS ENZYME INHIBITORS PEPTIDES, CYCLIC PHOSPHOPROTEIN PHOSPHATASE STEREOISOMERISM SPECTRUM ANALYSIS, MASS SLOVENIA MOLECULAR STRUCTURE NUCLEAR MAGNETIC RESONANCE AMINO ACID SEQUENCE |