Author/Editor | Rupnik, M; Grabnar, M; Gerič, B | |
Title | Binary toxin producing Clostridium difficile strains | |
Type | članek | |
Source | Anaerobe | |
Vol. and No. | Letnik 9 | |
Publication year | 2003 | |
Volume | str. 289-94 | |
Language | eng | |
Abstract | Clostridium difficile produces three toxins, TcdA, TcdB and CDT. TcdA and TcdB are single-stranded molecules acting as glucosyltransferases specific for small GTPases. CDT is an actin specific ADP-ribosylating binary toxin characteristically composed of two independent components, enzymatic CDTa (48 kDa) and binding CDTb (99 kDa). The cdtA and cdtB genes were sequenced in two CDT-positive strains of C. difficile (CD 196 and 8864) and at least two CDT-negative strains with truncated form of binary toxin gencs are known (VPI 10463 and C difficile genome strain 630). The prevalence of binary toxin producing strains is estimated to be from 1.6% to 5.5%, although a much higher proportion has been reported in some studies. The role of the binary toxin as an additional virulence factor is discussed. | |
Descriptors | CLOSTRIDIUM DIFFICILE VIRULENCE BACTERIAL TOXINS GENOME, BACTERIAL POLYMERASE CHAIN REACTION |