Author/Editor     Markelj, Gašper; Nikšič, Vesna
Title     Pomen in vloga antifosfolipidnih protiteles pri mladih z migrenskim glavobolom
Type     monografija
Place     Ljubljana
Publisher     Medicinska fakulteta
Publication year     2003
Volume     str. 37
Language     slo
Abstract     BACKGROUND. Antiphospholipid antibodies (aPL) are auto-antibodies directed against phospholipids and phospholipid-binding proteins. Among aPL anticardiolipin antibodies (aCL) and lupus anticoagulant (LA) antibodies are the most well known. They both are included in the laboratory criteria for the classification of the antiphospholipid syndrome (APS). In recent years, particular attention has been turned to the antibodies directed against beta2 glycoprotein I (anti-beta2GP1). It has been demonstrated, that they adhere to structures of the nervous tissue and to endothelial cells of brain vessels, and could be involved in various neurological manifestations. Many patients with APS have been reported having migraine in teenage years. These findings suggest the possible pathogenic role of aPL in migraine AIM. There have as yet been no longitudinal studies on aPL in pediatric migraine and no study has addressed the presence of anti-beta2GP1 antibodies. The aim of our study was to evaluate the prevalence of aPL in children with migraine and to determine their fine antigen specificity. In addition, with prospective follow-up of aCL, anti-beta2GP1 and LA we intended to determinate their clinical significance and possible pathogenic role in children with migraine. HYPOTHESIS. Antiphospholipid antibodies are present more frequently in children with migraine than in children with tension type headache and apparently healthy children in particular, anti-beta2GPI are characteristically present in children with migraine. METHODS. In our prospective study, 52 children with migraine and 22 children with tension type of headache were included. The group of children with tension type headache represented the control group. Results were compared to the values of aPL reported in the study with group of apparently healthy children, which represented second control group. (Abstract truncated at 2000 characters).
Descriptors     MIGRAINE
TENSION HEADACHE
ANTIBODIES, ANTIPHOSPHOLIPID
LUPUS COAGULATION INHIBITOR
ANTIBODIES, ANTICARDIOLIPIN
CHILD
GLYCOPROTEINS
ANTIBODIES, ANTINUCLEAR
PROSPECTIVE STUDIES