Author/Editor		Sakar, D; Pompe-Gotal, J; Belčić, Z; Blagović, S; Kanižaj, V
Title		Učinak terapijskih doza tiamulina na povećanu toksičnost monenzina u odbite prasadi
Translated title		Effect of therapeutic level of tiamulin on higher toxicity of monensin in weaned pigs
Type		članek
Source		Vet Arh
Vol. and No.		Letnik 61, št. 2
Publication year		1991
Volume		str. 67-82
Language		cro
Abstract		Investigated was the effect of the therapeutic concentration of tiamulin on the increased toxicity of monensin during their simultaneous medication in feed to 10 weaned pigs. The animals were fed over 10 initial days according to standrds for their age (50-65 days). Then the pigs were given monensin-sodium (100 ppm = 5.8 mg/kg b.w.) for 2 days and from the 7th-13th days, monensin and tiamulin (100 ppm = 5.8 mg/kg b.w.) simultaneously. While only monensin was given in feed (100 ppm), no changes in the health condition of the pigs were observed. On the other hand, 24 hours after the parallel medication of monensin and tiamulin the pigs became depressed and letargic, they were mostly laying down, but on stimulation they easily picked up. However, some animals manifested leg weakness and hindlimb ataxia. In 3-4 days all symptoms of depression and hypoactivity with stiffness disappeared. During the experiment the activity of plasmatic enzymes: creatine phosphokinase (CK), aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), aldolase (ALD) and malate dehydrogenase (MDH) were tested several times. Rapid elevation in the activity of CK, ALD, LDH and AST was noted on the 2nd and the 4th day following the introduction of the diet containing tiamulin and monensin. The increased activity of these four enzymes primarily reflects the impairment of the heart and skeletal muscles. A higher level of ALT and MDH, besides skeletal and heart muscle damage, is the sign of a degenerative alteration in the liver and renal tissue. Two weeks after the discontinuation of both antibiotics in the feed, the activity of mostly all tested enzymes was in the normal range and well equalized. This reflects a very moderate toxicity of monensin (dose 5.8 mg/kg b.w.) during a parallel medication with tiamulin (5.8 mg/kg b.w.) and also the restorative and restitutional processes in the impaired tissues
Descriptors		MONENSIN ANTIBIOTICS SWINE DRUG INTERACTIONS WEANING ANIMAL NUTRITION SWINE DISEASES