Author/Editor		Wikerhauser, T; Kutičić, V; Ražem, D
Title		A comparative study of the effect of gamma-irradiation on the infectivity of three different isolates of Toxoplasma gondii cysts in murine brains
Type		članek
Source		Vet Arh
Vol. and No.		Letnik 61, št. 2
Publication year		1991
Volume		str. 91-5
Language		eng
Abstract		A comparative study of the effect of gamma-irradiation on the infectivity of Toxoplasms gondii tissue cysts of three isolates, each of a geographically different origin, was performed. The isolates were from Yugoslavia (TG no. 3), the U.S.A. (me-49) and the P.R. China (NT). Tissue cysts in murine brains were irradiated with 0.4, 0.5, 0.6 and 0.7 kGy and their infectivity was assessed by bioassays on cats and/or mice. The source of irradiation was cobalt 60. A complete inactivation of the Yugoslav, American and Chinese isolates was achieved with 0.7, 0.4 and 0.5 kGy, respectively, although the Yugoslav and Chinese isolates showed a great reduction of infectivity already at the doses of 0.6 and 0.4 kGy, respectivey. Thus, the differences in radiosensitivity of T. Gondii tissue cysts, as reported by different authors, may be isolate-related
Descriptors		TOXOPLASMA GAMMA RAYS BRAIN DOSE-RESPONSE RELATIONSHIP, RADIATION TOXOPLASMOSIS, ANIMAL MICE, INBRED STRAINS MICE CATS