Author/Editor		Boršoš, Imre; Podboj, Jernej; Jenko, Klemen
Title		Maligni melanomi nosu in obnosnih votlin - naše izkušnje
Translated title		Malignant melanomas of the nose and paranasal sinuses - our experience
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 43, št. Suppl 3
Publication year		2004
Volume		str. 313-6
Language		slo
Abstract		Primary malignant mucosal melanoma of the nose and paranasal sinuses is a rare entity, but it is the most frequent melanoma of the head and neck. The etiopathogenesis of this type of melanoma is poorly understood; it is assumed that it originates from neuroectodermal mucosal cells. Sinonasal mucosal melanoma is primarily a disease of elderly adults. In the nose, the most frequent site of origin is the lateral nasal wall, the turbinates and the nasal septum, and in the sinuses it is the ethmoid. Its symptoms include unilateral nasal obstruction and nasal bleeding. Its treatment, if possible, should always be surgical. Fourteen patients with mucosal malignant melanoma of the nose and sinuses have been treated at our clinic over the past twenty years. Eleven melanomas were located in the nose and three in the ethmoidal cells. Nine of these patients were female and five male. Their ages ranged between 49 and 82 years. Sinonasal mucosal malignant melanoma is a highly malignant tumour. Distant metastases mean short survival following detection and at this stage of the disease the patient should have symptomatic treatment only.
Summary		Primarni maligni melanom sluznice nosu in obnosnih votlin je relativno redek, čeprav najpogostejši v predelu glave in vratu. Etiopatogeneza je slabo znana, omenja pa se, da se razvije iz melanocitov nevroektodermalnega porekla v sluznici. Sinonazalni sluznični maligni melanom je predvsem bolezen odraslih starejših. V nosu ga najbolj pogosto najdemo na stranski steni nosu oziroma na nosnih školjkah ter na nosnem pretinu, v obnosnih votlinah pa je najbolj pogost v sitkinih celicah. Bolniki se ponavadi pritožujejo zaradi zamašenosti nosu ter zaradi krvavitve iz nosu. Zdravljenje je po možnosti vedno kirurško. Na kliniki za otorinolaringologijo in cervikofacialno kirurgijo smo v zadnjih dvajsetih letih zdravili štirinajst bolnikov z malignim melanomom sluznice nosu in obnosnih votlin. Enajst bolnikov je imelo tumor v nosni votlini, trije pa v celicah sitke. Med temi bolniki je bilo devet žensk in pet moških, starih od 49 do 82 let. Sluznični maligni melanom sinonazalnega področja je vedno visoko maligni tumor. Ob metastazah se približuje terminalna faza bolezni in v tem stadiju je smiselno le simptomatsko zdravljenje.
Descriptors		NOSE NEOPLASMS PARANASAL SINUS NEOPLASMS MELANOMA SURVIVAL ANALYSIS TREATMENT OUTCOME