Author/Editor     Poredoš, Pavel
Title     Periferna arterijska bolezen in hiperlipidemija
Translated title     Peripheral artery disease and dyslipidemia
Type     članek
Source     Med Razgl
Vol. and No.     Letnik 43, št. Suppl 1
Publication year     2004
Volume     str. 123-6
Language     slo
Abstract     Peripheral arterial occlusive disease is one of the most common forms of atherosclerotic disease. Since atherosclerosis is a systemic disease, patients with peripheral artery disease are also at risk of coronary heart disease and cerebral artery atherosclerosis. Therefore, the presence of peripheral artery disease indicates high risk and effective preventative measures are necessary to reduce the possibility of fatal cardiovascular complications. In addition to smoking and diabetes, cholesterol is an important risk factor for the development and progression of peripheral atherosclerotic disease. The efficacy of treatment of hypercholesterolemia in persons with peripheral artery disease has not yet been researched in a major clinical study, but several small studies have shown that by reducing cholesterol in these patients, the progression of asymptomatic atherosclerotic plaques in peripheral arteries can be retarded. Subgroup analyses of major studies (4S, HPS) have also indicated that by reducing cholesterol in vascular patients, the frequency of occurrence of intermittent claudication can be reduced and that in patients who already have peripheral artery disease the risk due to the accompanying coronary heart disease is also significantly reduced. Patients with peripheral vascular disease are at high risk, therefore the target lipid values are the same as for coronary heart patients. Secondary prevention of atherosclerosis in vascular patients also does not differ from that in patients with coronary heart disease.
Summary     Periferna arterijska okluzivna bolezen sodi med najpogostejše pojavne oblike aterosklerotične bolezni. Glede na to, da je ateroskleroza sistemska bolezen, so bolniki s periferno arterijsko boleznijo močno ogroženi tudi s koronarno srčno boleznijo in aterosklerozo možganskih arterij. Zato prisotnost bolezni perifernih arterij kaže, da gre za zelo ogroženo osebo in so potrebni učinkoviti preventivni ukrepi, da zmanjšamo možnost usodnih srčno-žilnih zapletov. Holesterol je poleg kajenja in sladkorne bolezni pomemben dejavnik tveganja za nastanek in napredovanje periferne aterosklerotične bolezni. Učinkovitost zdravljenja hiperholesterolemije pri osebah s periferno arterijsko boleznijo doslej še ni bila proučena v pomembni klinični raziskavi, več manjših raziskav pa je pokazalo, da z zmanjševanjem holesterola pri teh bolnikih lahko zavremo napredovanje asimptomatskih aterosklerotičnih leh v perifernih arterijah. Tudi podskupinske analize večjih raziskav (4S, HPS) kažejo na to, da z zmanjševanjem holesterola pri žilnih bolnikih zmanjšamo pogostost pojavljanja intermitentne klavdikacije, in da pri bolnikih, ki že imajo periferno arterijsko bolezen, pomembno zmanjšamo zaplete, predvsem zaradi spremljajoče koronarne srčne bolezni. Pri perifernih žilnih bolnikih gre za zelo ogrožene osebe, zato so ciljne vrednosti lipidov enake kot pri koronarnih srčnih bolnikih, pa tudi sicer se sekundarna preventiva ateroskleroze pri žilnih bolnikih ne razlikuje od le-te pri bolnikih s koronarno srčno boleznijo.
Descriptors     ARTERIAL OCCLUSIVE DISEASES
PERIPHERAL VASCULAR DISEASES
HYPERLIPOPROTEINEMIA
HYPERCHOLESTEROLEMIA