Author/Editor		Gračner, Tomaž; Gračner, Bojan; Pahor, Dušica
Title		Comparative study of the efficacy of selective laser trabeculoplasty for pseudoexfoliation glaucoma and primary open-angle glaucoma
Translated title		Primerjava učinkovitosti selektivne laserske trabekuloplastike pri psevdoeksofoliacijskem glavkomu in primarnem glavkomu z odprtim zakotjem
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 73, št. 5
Publication year		2004
Volume		str. 439-43
Language		eng
Abstract		Background. To compare the efficacy of selective laser trabeculoplasty (SLT) as treatment of pseudoexfoliation glaucoma (PG) and primary open-angle glaucoma (POAG) in a prospective clinical study. Methods. Ten eyes of 10 patients suffering from uncontrolled PG (PG group) and 10 eyes of 10 patients with uncontrolled POAG (POAG group) were treated with a frequency-doubled, Q-switched Nd:YAG laser (532 nm). The baseline characteristics were similar in both groups. The intraocular pressure (IOP) was measured before the treatment and 1 day, 1 week, 1 month and 3, 6, 9, 12, 15, 18, 24, 30, and 36 months after the treatment. Success was defined as an IOP lowering exceeding 20% of pretreatment IOP. Any modification of hypotensive medication led to exclude the eye from the study. Statistical analysis comparing the two groups was carried out using the independent-sample t test for continuous variables and the Log-Rank test for survival analysis. All tests were conducted considering p < 0.05 as significant Results. The mean follow-up time was 22.8 months (SD 12.5) for the PG group and 24.3 months (SD 10.8% for the POAG group (n. s.). No significant difference was found between the two groups for mean pretreatment IOP (23.6 mm Hg (SD 5.7) in the PG group vs. 22.8 mm Hg (SD 2.4) in the POAG group) and for mean IOPs during the whole follow-up period. At all follow-up visits, the mean IOP reductions were smaller in the PG group than in the POAG group (7.0 mm Hg (SD 3.3) vs. 7.7 mm Hg (SD 2.0) at 24 months). However such difference was statistically signifficant only at 36 months (4.7 mm Hg [SD 1.1) vs. 8.3 mm Hg (SD 1.5)). At all follow-up visits, the mean percent IOP reduction was smaller in the PG group than in the POAG group (27.6% (SD 7.1) vs. 32.1% (SD 7.1) at 24 months). Furthermore, such a difference was statistically significant at 9, 12, and 36 months (21.8% (SD 1.6) vs. 34.1% (SD 4.7)). (Abstract truncated at 2000 characters).
Summary		Izhodišča. Primerjati učinkovitost selektivne laserske trabekuloplastike (SLT) pri zdravljenju psevdoeksfoliacijskega glavkoma (PG) in pri primarnem glavkomu z odprtim zakotjem (POAG) s prospektivno klinično raziskavo. Metode. 10 očes 10 bolnikov z neurejenim PG (skupina PG) in 10 očes 10 bolnikov z neurejenim POAG (skupina POAG) je bilo zdravljenih s frekvenčno podvojenim, Q preklopljenim laserjem Nd:YAG (532 nm). Osnovne značilnosti so bile podobne v obeh skupinah. Očesni pritisk (IOP) je bil izmerjen pred zdravljenjem in nato 1 dan, 1 teden, 1 mesec ter 3, 6, 9, 12, 15, 18, 24, 30 in 36 mesecev po SLT. Uspeh je bil določen z znižanjem IOP, ki je bilo večje kot 20% glede na IOP pred zdravljenjem. Vsaka sprememba lokalnega protiglavkomskega zdravljenja je vodila v izključitev očesa iz klinične raziskave. Statistična analiza primerjave dveh skupin je bila narejena s testom t neodvisnih vzorcev in testom Log-Rank za analizo preživetja. Pri vseh testih je bil p< 0,05 upoštevan kot statistično značilen. Rezultati. Za skupino PG je bil povprečen čas opazovanja 22,8 meseca (SD 12,5) za skupino POAG pa 24,3 meseca (SD 10,8), (stat. nezn.). Med povprečnima IOP pred zdravljenjem obeh skupin ni bilo statistično značilne razlike (23,6mm Hg (SD 5,7) v skupini PG proti 22,8 mm Hg (SD 2,4) v skupini POAG), prav tako pa tudi ne med povprečnima IOP po zdravljenju v celotnem času opazovanja. Pri vseh kontrolah po SLT je bilo povprečno znižanje IOP manjše v skupini PG kot v skupini POAG (7,0 mm Hg (SD 3,3) proti 7,7 mm Hg (SD 2,0) pri 24 mesecih), vendar pa je bila razlika statistično značilna le pri 36 mesecih (4,7 mm Hg (SD 1,1) proti 8,3 mm Hg (SD 1,5)). Pri vseh kontrolah po SLT je bil povprečen odstotek znižanja IOP manjši v PG skupini kot v POAG skupini (27,6% (SD 7,1) proti 32,1% (SD 7,1) pri 24 mesecih), razlika pa je bila statistično značilna pri 9,12 in 36 mesecih (21,8% (SD 1,6) proti 34,1% (SD 4,7)). (Izvleček skrajšan pri 2000 znakih).
Descriptors		GLAUCOMA, OPEN-ANGLE EXFOLIATION SYNDROME TRABECULECTOMY LASER SURGERY TREATMENT OUTCOME