Author/Editor		Šabovič, Mišo; Lavre, Simona; Keber, Irena
Title		Supplementation of wheat fibre can improve risk profile in patients with dysmetabolic cardiovascular syndrome
Type		članek
Source		Eur J Cardiovasc Prev Rehabil
Vol. and No.		Letnik 11, št. 2
Publication year		2004
Volume		str. 144-8
Language		eng
Abstract		Objectives We explored the effects of regular consumption of wheat fibre in patients with dysmetabolic cardiovascular syndrome (MCVS). Subjects and methods Forty-two patients with MCVS (mean age 49±8 years) were randomly assigned to a treated group (n=21) or to a control group (n=21). Patients in the treated group ate 10.5g of wheat fibre powder per day for the first week, followed by 21g per day for the next 4 weeks. A standard high-fibre diet was recommended to both groups. Blood pressure, metabolic parameters, fibrinolytic parameters and factor VII activity were measured at entry and after 5 and 9 weeks. Results After completing treatment, patients from both groups lost an average of 1kg weight. Consumption of wheat fibre resulted in a significant (P <0.05) decrease of systolic and diastolic blood pressure, fasting glucose, glucose 2h after oral glucose challenge (OGC), total cholesterol, low-density and high-density lipoprotein cholesterol, ranging from 7 to 18%. Furthermore, no significant reductions in fasting insulin, insulin 1 and 2h after OGC, and glucose 1h after OGC were found, whereas no differences in fibrinolytic parameters and factor VII activity were observed. Almost all beneficial effects of wheat fibre diminished 4 weeks after its withdrawal. In the non-treated group only a significant decrease of systolic pressure was observed. Conclusions Our results suggest that supplementation of wheat fibre, not just a standard high-fibre diet, may improve cardiovascular risk profile in patients with MCVS, in a manner independent of weight reduction.
Descriptors		WHEAT DIETARY FIBER BLOOD PRESSURE FIBRINOLYSIS FACTOR VII LIPOPROTEINS RISK FACTORS OBESITY HYPERLIPIDEMIA HYPERTENSION BODY MASS INDEX BLOOD GLUCOSE INSULIN