Author/Editor		Pogorelc-Erjavec, Andreja; Babnik, Janez
Title		Ocena napovedne vrednosti dejavnikov tveganja za bakterijsko okužbo pri novorojenčku
Type		članek
Source		In: Novak-Antolič Ž, editor. Bakterijske okužbe v perinatologiji. 12. Novakovi dnevi z mednarodno udeležbo; 2004 maj 14-15; Laško. Ljubljana: Slovensko zdravniško društvo, Združenje za perinatalno medicino,
Publication year		2004
Volume		str. 14-21
Language		slo
Abstract		Background. Early-onset neonatal sepsis is a low incidence disease (1-5/1000 live births) bul still associated with an appreciable mortality (10-30%). The incidence as well as mortality are higher in preterm neonates. The neonates are often asymptomatic at birth or they have signs which are not specific for the infection (for example: respiratory distress syndrome in preterm baby). Very often laboratory test: are not helpful early in the course of the disease. In such circumstances we use several maternal and neonatal risk factors for deciding about the use of antibiotic therapy. Method. We retrospectively analyzed maternal and neonatal risk factors for proven as well as clinically suspected sepsis in 33.215 neonates born in Ljubljana Maternity from 1997 to 2002. Univariate as well as multivariate statisical analyses were used. Results. The incidence of proven early bacterial infection was 2,3/1000 live births and that of clinically suspected one 20,7/1000 live births. Logistic regression analysis identified risk factors for proven as well as for clinically suspected bacterial infection in newborn. For both entities low gestational age was a significant risk factor (p=0,000). With every additional week of the gestational age of the neonate the risk for infection was 20% lower. Early-onset respiratory failure was an independent risk factor in both groups of patients (p=0,000). There was statistically significant association between low 5 minutes Apgar score and proven as well as clinically suspected sepsis (p=0,019; p=0,025). We also found statistically significant association with prolonged rupture of membranes (p=0,000) and amnionitis {p=0,082; OR=1,7, CI=0,9-3,3) in the group of clinically suspected sepsis. (Abstract truncated at 2000 characters).
Descriptors		INFANT, NEWBORN, DISEASES BACTERIAL INFECTIONS INFANT, NEWBORN RISK FACTORS