Author/Editor		Felc, Zlata; Ilijaš-Trofenik, Ana
Title		Bakterijske okužbe v zgodnjem neonatalnem obdobju
Translated title		Early-onset neonatal bacterial infections
Type		članek
Source		In: Novak-Antolič Ž, editor. Bakterijske okužbe v perinatologiji. 12. Novakovi dnevi z mednarodno udeležbo; 2004 maj 14-15; Laško. Ljubljana: Slovensko zdravniško društvo, Združenje za perinatalno medicino,
Publication year		2004
Volume		str. 68-73
Language		slo
Abstract		Background. Early-onset bacterial infections occur in the first 7 days of life; are aquired by vertical transmission from the mother. They are still a significant cause of neonatal morbidity and mortality. Conclusions. Bacterial infections, usually fulminant, multisystem infections, remain the leading cause of early-onset neonatal sepsis. In western countries, the incidence of early-onset neonatal sepsis varies from 1 to 5 cases per 1,000 live births; group B streptococci (GBS, species designation Streptococcus agalactiae), Escheri.chia coli and Lysteria monocytogenes are the most common organisms isolated. Other pathogens, including coagulase-negative staphylococci, enterococci, alpha-hemolytic streptococci, and pneumococci, are seen less often. Although signs and symptoms of early-onset neonatal sepsis are often subtle and nonspecific, once the clinical diagnosis is obvious, the infant is already critically ill. For these reasons, it is imperative that empiric antimicrobial therapy be instituted immediately after obtaining samples for culture rather than waiting for culture results. For early-onset neonatal sepsis in western countries, the antimicrobal regimen should provide coverage against GBS, Escherichia coli, and Lysteria monocytogenes. The combination of ampicillin and aminoglycoside is frequently used.
Descriptors		INFANT, NEWBORN, DISEASES BACTERIAL INFECTIONS SEPSIS PNEUMONIA OTITIS MEDIA INFANT, NEWBORN GASTROENTERITIS OPHTHALMIA NEONATORUM