Author/Editor		Štucin-Gantar, Irena; Babnik, Janez; Šinkovec, Jasna; Wraber, Branka; Kornhauser-Cerar, Lili; Bregant, Lev; Domjan-Arnšek, Andreja
Title		Vloga prenatalnega vnetja pri nastanku bronhopulmonalne displazije
Type		članek
Source		In: Novak-Antolič Ž, editor. Bakterijske okužbe v perinatologiji. 12. Novakovi dnevi z mednarodno udeležbo; 2004 maj 14-15; Laško. Ljubljana: Slovensko zdravniško društvo, Združenje za perinatalno medicino,
Publication year		2004
Volume		str. 159-71
Language		slo
Abstract		Background. Chorioamnionitis is one of the more important causes of preterm delivery. Spread of infection to the fetus leads to the syndrome of fetal inflammatory response syndrome, which slows down the process of pulmonary alveolisation. The purpose of our study was to determine the role of prenatal infection in the development of bronchopulmonary dysplasia (BPD). Methods. We included 138 newborns born before the 30. week of gestation in the period from September 2000 until June 2002. In the cord blood and in the aspirate of the stomach concentrations of IL-6 and IL-8 were determined. Placenta was histologically examined to confirm or exclude chorioamnionitis. Newborns needing artificial ventilation aspirate of trachea for IL-6 and IL-8 were taken in regular intervals. Results. Among 138 newborns 26 (19%) had BPD, 58 (42%) only respiratory distress syndrome (RDS), and the rest (39%) represented the control group. Concentrations of IL-6 and IL-8 in cord blood and stomach aspirate were good markers for histological (HHA) and clinical chorioamnionitis. The concentration of IL-6 in cord blood had statistically significant predictive value for the outcome without RDS and the concentration of IL-8 in the stomach aspirate for the development of BPD. The differences in the first IL-6 and IL-8 concentrations in the tracheal aspirates were mostly dependent on HHA, and there were no differences among newborns with uncomplicated RDS and the newborns with BPD. Intensive artificial respiratory support caused transitory elevation of IL-6 and IL-8 concentrations in tracheal aspirates. Multivariate analysis showed that BPD was the consequence of intensive artificial respiratory support and »quick« reanimation in delivery room (increase in Apgar score for more than two points from the 1. to the 5. minute) and prenatal infection. (Abstract truncated at 2000 characters).
Descriptors		CHORIOAMNIONITIS BRONCHOPULMONARY DYSPLASIA RESPIRATORY DISTRESS SYNDROME INTERLEUKIN-6 INTERLEUKIN-8 INFANT, NEWBORN INFANT, PREMATURE ROC CURVE