Author/Editor		Milivojevič, Nataša; Krisch, Igor; Sket, Dušan; Živin, Marko
Title		The dopamine D(1) receptor agonist and D(2) receptor antagonist LEK-8829 attenuates reinstatement of cocaine-seeking in rats
Type		članek
Source		Naunyn Schmiedebergs Arch Pharmacol
Vol. and No.		Letnik 369, št. 6
Publication year		2004
Volume		str. 576-582
Language		eng
Abstract		Various dopaminergic drugs have been studied for their efficacy in the treatment of cocaine addiction. Pretreatment with either selective dopamine D(1) receptor agonists or selective dopamine D(2) receptor antagonists prevents reinstatement of cocaine-seeking in animal models of drug craving and relapse. We tested a novel ergoline derivative with combined D(1) agonistic and D(2) antagonistic effects, 9,10-didehydro- N-methyl- N-(2-propynyl)-6-methyl-8beta-aminomethylergoline bimaleate (LEK-8829), for its effects on cocaine-seeking in the intravenous cocaine self-administration model in rats. Pretreatment with systemic injections of LEK-8829 attenuated reinstatement of cocaine-seeking induced by cocaine priming injections and diminished cocaine intake in cocaine self-administration sessions. LEK-8829 itself did not induce reinstatement of cocaine-seeking and did not maintain intravenous self-administration. The results of our study indicate that LEK-8829 is a candidate medication for the treatment of cocaine craving in cocaine addiction.
Descriptors		SUBSTANCE DEPENDENCE COCAINE ERGOLINES RECEPTORS, DOPAMINE D1 RECEPTORS, DOPAMINE D2 SELF ADMINISTRATION RATS, WISTAR