Author/Editor		Poredoš, Peter; Šuran, David
Title		Vpliv hujšanja na endotelno funkcijo
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		2003
Volume		str. 67
Language		slo
Abstract		BACKGROUND. Obesity and accompanying metabolic disorders represent one of the most significant risk factors for vascular diseases. For this reason, certain subclinical vascular changes are expected even in obese subjects without obvious clinical manifestations. Endothelial dysfunction is one of the earliest functional abnormalities in the process of atherogenesis. It is known that weight loss reduces the risk of cardiovascular events in obese subjects. However, it is not known, whether the weight loss is accompanied by a complete recovery of metabolic changes and functional vascular disorders and what lag time after the start of weight reduction is needed for the expected improvement. AIM AND HYPOTHESIS. The aim of our prospective study was to find out if noticeable changes in endothelial function can be observed already one week after the start of weight reduction program. Furthermore, we tried to determine whether the improvement of endothelial function is associated with weight reduction, improvement of metabolic disorders or other factors. SUBJECTS AND METHODS. The studied group comprised of 41 obese women who followed a low-calorie diet program, including moderate physical activity, and the control group consisted of 21 normal-weight women. The weight reduction program lasted for 6 months. Before its beginning, after one week and at the end of the weight reduction program, anthropometric measures and laboratory biochemical investigations were performed. Beside this the flow-mediated dilation of brachial artery was determined using ultrasound. RESULTS. Before starting the weight reduction program, the following metabolic disorders were observed in the obese compared to the lean women: dyslipidemia, elevated insulin level and insulin resistance. Obese women had elevated leptin level, decreased adiponectin level and elevated level of PAI-1 antigen and activity, CRP and TNF R1. (Abstract truncated at 2000 characters).
Descriptors		OBESITY WEIGHT LOSS BRACHIAL ARTERY VASODILATION INSULIN RESISTANCE DIET, REDUCING CHOLESTEROL TRIGLYCERIDES INSULIN TUMOR NECROSIS FACTOR BODY MASS INDEX