Author/Editor     Banić, Vladimir; Mark, Igor
Title     Kaj se zgodi s postsinaptičnimi receptorji pri parkinsonizmu?
Type     monografija
Place     Ljubljana
Publisher     Medicinska fakulteta
Publication year     2003
Volume     str. 53
Language     slo
Abstract     BACKGROUND. Parkinsonism is a central nervous system neurotransmitter disorder. Lesion can be either presynaptic or combined presynaptic-postsynaptic and it involves motor and nonmotor pathways. The damage to the motor circuit results in bradykinesia, rigidity and tremor; the damage to the cognitive circuit results in dementia and frontal disorder; the damage to the affective circuit results in depression. AIM. The purpose of our research was to locate the site of the lesion in the CNS pharmacodynamically either as presynaptic or combined presynaptic-postsynaptic; to compare these pharmacodynamic categories to the established clinical classification; and to find out wheather these categories differ in non-motor (cognitive and affective) circuits involvement. HIPOTHESES. As the disease progresses over years postsynaptic receptors can: a) stay intact, b) remain irreversibly damaged, 3) get damaged later on, 4) be initially damaged, only to recover later on. When additional postsynaptic damage in the motor circuit exists, more profound cognitive impairment is expected. Similarly additional postsynaptic damage in the motor circuit exists, more profound affective impairment is expected. METHODS. The research has been set up as a prospective historical study of 22 parkinsonian patients, all of whom had been tested with apomorphine (APO) at least three years earlier. First, we examined patients neurologicaly under the supervision of the neurologist. Motor performance was assesed in all of them using the Unified Parkinson's Disease Rating Scale (UPDRS) in »off« state. All patients filled in several questionnaires assesing cognitive impairment, depression and quality of life. In the second part, apomorphine test was done and another UPDRS performed. Finally, the results of both tests were compared. For the statistical analysis independent-t-test in small samples and Pearson's correlation method were used. (Abstract truncated at 2000 charactes).
Descriptors     PARKINSON DISEASE
RECEPTORS, NEUROTRANSMITTER
APOMORPHINE
NEUROLOGIC EXAMINATION
QUALITY OF LIFE
COGNITION DISORDERS
DEPRESSIVE DISORDER
QUESTIONNAIRES