Author/Editor		Šega, Saša; Wraber, Branka; Mesec, Anton; Horvat, Alenka; Ihan, Alojz
Title		IFN-beta1a and IFN-beta1b have different patterns of influence on cytokines
Type		članek
Source		Clin Neurol Neurosurg
Vol. and No.		Letnik 106
Publication year		2004
Volume		str. 255-8
Language		eng
Abstract		Multiple sclerosis is characterized by elevated levels of proinflammatory cytokines produced by Th1 cells and decreased levels of anti-inflammatory cytokines produced by Th2 cells. IFN-beta treatment shifts the immune response from the Th1 to Th2 pattern, thus enhancing the production of anti-inflammatory Th2 cytokines such as IL-4, IL-10, and decreasing the production of proinflammatory Thl cytokines such as IFN-gamma. To determine which IFN-beta has the stronger immunomodulatory effect we compared the levels of IL-4, IL-10, and IFN-gamma of 12 relapsing-remiting MS patients treated with IFN-beta1b (Betaferon®) with those of 10 patients treated with IFN-beta1a (Avonex®). There were no statistically significant differences in duration of disease, number of relapses before and during treatment, and in EDSS after 2 years of treatment. After 1 year of treatment the concentration of IFN-gamma was significantly lower in the Betaferon® group, and concentrations of IL-4 and IL-10 were significantly higher in the Avonex® group. It appears that IFN-beta1b has a downregulatory effect on both Thl and Th2 cytokines, while IFN-beta1a causes a shift of the cytokine profile toward the Th2 phenotype. These two IFN have different influences on the pattern of cytokines in MS: IFN-beta1 a enhances the production of anti-inflammatory cytokines IL-4 and IL-10 and IFN-beta1b decreases the production of the proinflammatory cytokine IFN-gamma.
Descriptors		MULTIPLE SCLEROSIS INTERFERON-GAMMA, RECOMBINANT INTERLEUKIN-4 INTERLEUKIN-10 INTERFERON TYPE II TREATMENT OUTCOME