Author/Editor		Šabovič, Mišo; Kloboves-Prevodnik, Veronika; Keber, Dušan
Title		Comparison of fibrinolytic activity in the femoral vein and the right atrium
Type		članek
Source		Blood Coagul Fibrinolysis
Vol. and No.		Letnik 15
Publication year		2004
Volume		str. 245-8
Language		eng
Abstract		Local fibrinolytic activity in Ieg veins has not been completely explored. Since the blood in the right atrium is a mixture of venous blood supplied from the whole body, the fibrinolytic activity in the right atrium may be used as a reference value to which local values can be compared in order to identify local hyperfibrinolysis or hypofibrinolysis. We compared fibrinolytic parameters (tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor (PAI-1), euglobulin clot lysis time] measured in the femoral vein with those in the right atitum. The blood samples were obtained during right heart catheterization of 51 patients. No differences in t-PA antigen (9.6 ng/ml (6.6-11.9 ng/ml) versus 8.1 ng/m ((6.7-11.3 ng/ml)) (median (interquartile range)) and PAI-1 antigen (9.3 ng/ml (7.1-16.0 ng/ml) versus 8.4 ng/ml (5.5-14.3 ng/ml)) levels were found, whereas t-PA activity was significantly higher (183 IU/ml (39-1097 IU/ml) versus 92 IU/ml (5-680 IU/ml), P< 0.05), PAI-1 activity significantly lower (7.2 IU/ml (5.1-10.2 IU/ml) versus 7.9 IU/ml (5.8-10.3 IU/ml), P< 0.05), and the euglobulin clot lysis time was signifficantly shorter (6.21000/min (4.8-10.0 1000/min) versus 5.51000/min (4.1-9.1 1000/min), P< 0.051 in the femoral vein compared with the right atrium. In conclusion, our results show that local fibrinolytic activity in the femoral vein is higher than in the right atrium, and thus demonstrate that increased local fibrinolysis is present in leg veins.
Descriptors		FEMORAL VEIN HEART ATRIUM FIBRINOLYSIS ALTEPLASE PLASMINOGEN ACTIVATOR INHIBITOR 1 CLOT RETRACTION HEART CATHETERIZATION