Author/Editor		Molnar-Novak, Helena; Bedernjak-Bajuk, Nataša
Title		Agranulocitoza in hepatitis po metimazolu pri bolnici z bazedovko, ki je nastala po terapiji z radiojodom
Translated title		Methimazole induced agranulocitosis and hepatitis in patient with Graves disease appeared after radioiodine treatment
Type		članek
Source		In: Bručan A, Gričar M, Vajd R, editors. Urgentna medicina: izbrana poglavja. Zbornik 11. mednarodni simpozij o urgentni medicini; 2004 jun 9-12; Portorož. Ljubljana: Slovensko združenje za urgentno medicino,
Publication year		2004
Volume		str. 268-71
Language		slo
Abstract		A 75- year old woman was treated with one oral dose of radioiodine (RAI) because of toxic nodular goitre. Before radioiodine therapy serum thyrotropin receptor antibodies (TSI), thyroid peroxidase antibodies (antiTPO) and thyroglobulin antibodies (antiTg) were negative. Three months after treatment the patient developed severe hyperthyroidism with appearance of TSI. Methimazole therapy was started. Four weeks later agranulocytosis and mild liver failure were found. Methimazole was stopped and the filgrastima (granulocyte colony stimulating factor- (G -CSF)) and antibiotic treatment was initiated. After 4 days neutrophil count and liver tests become normal. A second administration of RAI was found successful. At the follov up she developed hypothyroidism and started with L thyroxine therapy.
Descriptors		GRAVES' DISEASE IODINE RADIOISOTOPES METHIMAZOLE AGRANULOCYTOSIS HEPATITIS, TOXIC AGED