Author/Editor		Pinter, Bojana; Pretnar-Darovec, Alenka; Verdenik, Ivan; Anderle, Alojzija; Beseničar, Lara; Bučar, Martina; Fakin, Cvetka; Kovač, Vilma; Maurič, Danilo; Mugoša, Dragoslav; Podlipnik, Marjeta; Rožič-Vičič, Nives
Title		Sprejemljivost jemanja ultranizkodozne oralne kontracepcije z 20 mikrog etinilestradiola in 75 mikrog gestodena med mladimi ženskami v multicentrični klinični raziskavi
Translated title		Acceptability of ultra low-dose oral contraceptives containing 20 microg ethinyl estradiol and 75 microg gestodene in young females in a multicenter clinical study
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 73, št. 6
Publication year		2004
Volume		str. 477-80
Language		slo
Abstract		Background. The acceptability of ultra low-dose oral contraception (OC) among young females after three and six cycles of treatment was assessed. Methods. In the clinical prospective study, carried out in 10 outpatient clinics in Slovenia, 240 healthy women aged 1630 years choosing ultra low-dose OC (20 microg ethinyl estradiol and 75 microg gestodene) were included. Results. The average age was 20.6 (+- 3.5) years. After three cycles (N = 228) there were no changes in body weight or blood pressure; one tenth (9.6%) of women reported irregular bleeding and 3.9% weight gain while other side effects occurred rarely. After three cycles 88.3% of the women initially included corztinued OC use (5% discontinued the use due to side effects). After six cycles (N = Z95) there were no changes in blood pressure; body weight statistically significantly increased for 0.5 kg providing the weight changes during the time were not considered. Fewer women reported side effects (3.6% irregular bleeding, 2.6% weight gain and rarely other side effects). After six cycles 75.0% of the women initially included continued the OC use (7.5% discontinued the use due to the side effects). Conclusions. The study has shown good clinical acceptability of ultra low-dose OC by young females.
Summary		Izhodišča. Želeli smo ugotoviti, kakšna je sprejemjivost jemanja ultranizkodozne oralne kontracepcije (OKC) med mlajšimi ženskami po treh in šestih ciklusih jemanja tablet. Metode. V klinično prospektivno raziskavo smo v 10 ginekoloških ambulantah v Sloveniji vključili 240 zdravih preiskovank, starih od 16 do 30 let, ki so za kontracepcijsko metodo izbrale ultranizkodozno OKC z 20 mikrog etinilestradiola in 75 mikrog gestodena v dnevnem odmerku. Rezultati. Povprečna starost preiskovank je bila 20, 6 (± 3,5) leta. Po treh ciklusih jemanja OKC (N = 228) se telesna teža in krvni tlak nista spremenila; 9,6% preiskovank je navajalo motnje ciklusa in 3,9% povečanje telesne teže, drugi neželeni učinki so bili redkejši. Z jemanjem OKC je nadaljevalo 88,3% vseh vključenih preiskovank (5,0% preiskovank je prenehalo jemanje zaradi neželeuih učinkov). Po šestih ciklusih jemanja OKC (N = 195) se krvni tlak. ni spremenil; telesna teža se je, če ne upoštevamo spreminjanja teže s starostjo, značilno povečala za 0,5 kg. Drugi neželjeni učinki so bili redkejši (3,6% motnje ciklusa, 2,6% povečanje telesne teže in redkeje drugi učinki). Po šestih ciklusih je jemanje OKC nadaljevalo 75,0% vseh vključenih preiskovank (zaradi neželenih učinkov je prenehalo jemanje 7,5% vseh preiskovank). Zaključki. V raziskavi smo ugotovili dobro klinično sprejemljivost ultranizkodozne OKC med mladimi ženskami.
Descriptors		CONTRACEPTIVES, ORAL, COMBINED ETHINYL ESTRADIOL-NORGESTREL COMBINATION BODY WEIGHT BLOOD PRESSURE ADULT ADOLESCENCE PROSPECTIVE STUDIES