Author/Editor		Zver, Samo; Kokalj-Vokač, Nadja; Zagradišnik, Boris; Erjavec, Alenka; Zagorac, Andreja; Preložnik-Zupan, Irena; Černelč, Peter
Title		T cell prolymphocytic leukemia with new chromosome rearrangements
Type		članek
Source		Acta Haematol
Vol. and No.		Letnik 111, št. 3
Publication year		2004
Volume		str. 168-70
Language		eng
Abstract		A 77-year-old woman presented to the outpatient hematology clinic in August 2001 with leukocytosis; recurrent bacterial infections, sweating and weight ioss. Bone marrow biopsy showed 80% infiltration with lymphoid cells having a profymphocytic morphology. Flow-cytometric immunophenotype analysis showed that over 80% of the cells were positive for CD2, CD3, CD4, CD5 and CD7 antigens and negative for terminal deoxynucleotidyl transferase and CD1a antigens. T cell prolymphocytic leukemia (T-PLL) was diagnosed on the basis of these findings. The diagnosis was later confirmed by cytogenetic analysis and fluorescence in situ hibridization. The patient had the following karyotype: 46,X,der(X)t(X;3) (q28;p25) t(X;16)(p14;q12), der(3) t(X;3)(q28;p25), der(6) t(X;6) (p14;q25), (8) (q10), del(11) (q14q23), der(13) t (5;13) (q34;p11), der(13) t(13;14)(q22;q11), inv(14)(q11q32), der(16) t(X;16)(q28;q12), r(17)(p13q21), der(20) t(17;20) (q21; c. q13),22p+. The cytogenetic rearrangements der(6)t(X;6) (p14;q25), der(13)t(13;14)(q22;q11),t(5;13)(q34;p11), r(17) (p13q21) and t(17;20)(q21;q13) have not been described previously in the literature in patients with T-PLL.
Descriptors		LEUKEMIA, PROLYMPHOCYTIC LEUKEMIA, T-CELL CHLORAMBUCIL KARYOTYPING AGED FLOW CYTOMETRY IN SITU HYBRIDIZATION, FLUORESCENCE GENE REARRANGEMENT, T-LYMPHOCYTE