Author/Editor		Mekiš, Dušan; Kamenik, Mirt
Title		A randomised controlled trial comparing remifentanil and fentanyl for induction of anaesthesia in CABG surgery
Type		članek
Source		Wien Klin Wochenschr
Vol. and No.		Letnik 116, št. 14
Publication year		2004
Volume		str. 484-8
Language		eng
Abstract		Summary. Introduction: In a prospective randomised trial we studied haemodynamic stability during induction of anaesthesia for CABG surgery in patients receiving remifentanil-propofol or fentanyl-propofol anaesthesia. Methods: Fifty-four patients scheduled for elective CABG surgery were studied. Anaesthesia was induced with propofol and pancuronium. The patients were randomly assigned to two groups according to the opioid used during the induction. The remifentanil group received 0.5 microg kg-1min-1 of the drug and the fentanyl group received 5microgkg-1. We measured blood pressure, central venous pressure and heart rate continuously for 15min before and 30min after orotracheal intubation. We also recorded use of rescue medication for maintaining the mean arterial pressure between 65 and 85 mmHg. Results: After induction of anaesthesia the mean arterial pressure and heart rate decreased significantly in both groups (P<0.05). After orotracheal intubation the mean arterial pressure and heart rate increased significantly in the fentanyl group but not in the remifentanil group (P<0.05). The incidence of hypertonic events necessitating the use of rescue medication was significantly higher in the fentanyl group (P<0.05). Conclusions: Our results show more stable haemodynamics after induction of anaesthesia in CABG surgery in patients receiving remifentanil-propofol than in patients receiving fentanyl-propofol.
Descriptors		FENTANYL PROPOFOL PANCURONIUM ANESTHESIA, INTRAVENOUS CORONARY ARTERY BYPASS RANDOMIZED CONTROLLED TRIALS TREATMENT OUTCOME HEART RATE CENTRAL VENOUS PRESSURE BLOOD PRESSURE