Author/Editor		Jereb, Matjaž
Title		Vpliv mesta okužbe in vrste bakterije na koncentracijo prokalcitonina v serumu
Type		monografija
Place		Ljubljana
Publisher		Univerza v Ljubljani, Medicinska fakulteta
Publication year		2004
Volume		str. 117
Language		slo
Abstract		Sepsis, bacterial meningitis, infective endocarditis, and bacterial pneumonia are common diseases in our place. Despite of advance in antimicrobial and intensive care medicine, mortality from the diseases remains unacceptably high. Rapid diagnosis and therapy have crucial influence on clinical outcomes. Patients with viral infections have not so rarely clinical and laboratory parameters of bacterial infection which usually lead to unnecessary antibiotic therapy. Delay of antimicrobial treatment could be on the other side fatal in case of unrecognized and noncharacteristic bacterial infection. During the last few years several studies have been reported on the new inflammation peptid procalcitonin, which concentration increases in the setting of bacterial infection. In the present study we wanted to find out, whether there is any difference in plasma procalcitonin level between patients with viral infection and patients with bacterial infection of different locations. The aim of this study was to find out also the influence of different infection locations or type of bacteria on procalcitonin level. 30 patients with tick-borne encephalitis, 30 patients with bacterial meningitis, 30 patients with sepsis, 30 patients with bacterial pneumonia and 23 patients with infective endocarditis were included in the prospective clinical study. The mean plasma procalcitonin level in patients with tick-borne encephalitis was 0.25 ng/ml, in patients with bacterial meningitis 11.70 ng/ml, in patients with sepsis 73.47 ng/ml, in patients with bacterial pneumonia 10.30 ng/ml, and in patients with infective endocarditis 6.8 ng/ml. Differences in procalcitonin plasma level, between viral infection and bacterial infection of different locations, were statistically significant (p < 0.001). Patients with sepsis had significant higher procalcitonin level than patients with localised bacterial infection (p = 0.005). (Abstract truncated at 2000 characters).
Descriptors		MENINGITIS, BACTERIAL ENCEPHALITIS, TICK-BORNE SEPSIS ENDOCARDITIS, BACTERIAL CALCITONIN PNEUMONIA, BACTERIAL GLASGOW COMA SCALE APACHE CONSCIOUSNESS DISORDERS PROSPECTIVE STUDIES