Author/Editor		Sočan, Maja; Frelih, Tatjana; Janet, Evgen; Petraš, Teodora; Peternelj, Brigita
Title		Reactions after pneumococcal vaccine alone or in combination with influenza vaccine
Type		članek
Source		Vaccine
Vol. and No.		Letnik 22
Publication year		2004
Volume		str. 3087-91
Language		eng
Abstract		We studied adverse reactions to immunisation in 541 individuals receiving simultaneous pneumoccocal and influenza vaccination, and in 320 recipients of pneumococcal vaccine alone. Five days after immunisation, the participants completed a questionnaire covering systemic and local reactions to vaccination. Adverse effects were rated as mild if they did not interfere with the participant's daily activities, and moderate or serious if they moderately or markedly restricted these activities. There were no differences between the groups regarding general malaise, headache, myalgias and elevated body temperature. Redness at the injection site, but not soreness or swelling, occurred more frequently in individuals immunised simultaneously with both vaccines. Except for fever and local swelling, adverse reactions were significantly more frequent in women than in men in study groups. The rate of adverse reactions was higher in individuals less then 65 years of age than in older participants. Local reactions were reported by 358 (41.6%) participants, but they were mild and soon subsided. No serious reactions were reported. pneumococcal and influenza vaccine can be safely administered simultaneously.
Descriptors		STREPTOCOCCUS PNEUMONIAE BACTERIAL VACCINES INFLUENZA VACCINE SEX FACTORS QUESTIONNAIRES