Author/Editor     Avčin, T; Markelj, G; Nikšič, V; Rener-Primec, Z; Čučnik, S; Zupančič, M; Rozman, B; Neubauer, D
Title     Estimation of antiphospholipid antibodies in a prospective longitudinal study of children with migraine
Type     članek
Source     Cephalalgia
Vol. and No.     Letnik 24
Publication year     2004
Volume     str. 831-7
Language     eng
Abstract     The aim of this study was to determine the prevalence and clinical significance of antiphospholipid antibodies (aPL) in children with migraine. The values of anticardiolipin (aCL) and antibeta2 glycoprotein I (antibeta2GPI) antibodies were assayed by an ELISA method in 52 children with migraine and 22 children with tensiontype headache. The control group consisted of 61 apparently healthy children at regular preventive visits. Two monoclonal beta2GPI dependent aCL (HCAL and EY2C9) were used as calibrators. Lupus anticoagulant (LA) was determined by a modified dilute Russell viper venom time test. Persistently positive aPL were observed during the follow-up in 16.3% of children with migraine (9.3% for aCL, 7.0% for antibeta2GPI and 0% for LA) and in 16.7% of children with tension-type headache (11.1% for aCL, 5.6% for antibeta2GPI and 0% for LA). The prevalence of aPL did not differ significantly between patient groups and healthy children. The prevalence of aPL does not appear to be increased in an unselected group of children with migraine, however, the possible role of aPL in individual cases of paediatric migraine can not be excluded.
Descriptors     MIGRAINE
TENSION HEADACHE
ANTIBODIES, ANTIPHOSPHOLIPID
ANTIBODIES, ANTICARDIOLIPIN
GLYCOPROTEINS
ANTIBODIES, MONOCLONAL
LUPUS COAGULATION INHIBITOR
ANTIBODIES, ANTINUCLEAR
ENZYME-LINKED IMMUNOSORBENT ASSAY
CHILD
PROSPECTIVE STUDIES