Author/Editor		Jazbec, Janez
Title		Tveganje za sekundarno maligno neoplazmo pri otrocih z rakom
Translated title		The risk for second malignant neoplasm after childhood cancer
Type		monografija
Place		Ljubljana
Publisher		Univerza v Ljubljani, Medicinska fakulteta
Publication year		2004
Volume		str. 88
Language		slo
Abstract		The number of long time survivors of childhood cancer treatment is constantly increasing over the last decades as a result of advances in diagnosis and treatment. The occurrence of second neoplasms is one of most serious late effects observed in cancer survivors. The risk of secondary neoplasm was studied in a cohort of 1577 patients treated for childhood cancer registered in the Cancer Registry of Slovenia between 1960 and 2000. The time at risk was defined from the date at diagnosis of first malignancy to the time of death or the end of the study. The most frequent primary malignancies were: acute leukemia 28.5%, central nervous system tumors 21.3% and lymphomas 16.6%. Median observation time was 7.8 years. Forty-eight patients developed second neoplasms. Central nervous system tumors, acute leukemias and thyroid carcinoma were most frequent second neoplasms. The cumulative risk for second neoplasm in the entire cohort was 0.06 % at five years, 5. l % at 15 years and 12.6% at 25 five years after diagnosis of first cancer. The overall survival after second neoplasm was 65% ten years after the diagnosis of second neoplasm. Patients after treatment of childhood cancer are at special risk for subsequent neoplasms and long-term follow up is mandatory.
Descriptors		NEOPLASMS NEOPLASMS, SECOND PRIMARY POLYMORPHISM (GENETICS) GLUTATHIONE TRANSFERASES GENES, P53 RISK FACTORS METHYLENETETRAHYDROFOLATE DEHYDROGENASE LEUKEMIA, LYMPHOCYTIC, ACUTE MULTIVARIATE ANALYSIS SURVIVAL ANALYSIS POLYMERASE CHAIN REACTION CHILD