| Author/Editor | Vene, Nina | |
| Title | Spremembe strjevanja krvi pri bolnikih z atrijsko firbrilacijo | |
| Type | monografija | |
| Place | Ljubljana | |
| Publisher | Univerza v Ljubljani, Medicinska fakulteta | |
| Publication year | 2004 | |
| Volume | str. 62 | |
| Language | slo | |
| Abstract | Chronic atrial fibrillation is associated with hemostatic changes and with increased risk of thrombotic events, which depends on coexistent risk factors. The aim of our first study was to assess the association of hemostatic changes with risk factors and the prognostic value of hemostatic changes in patients with chronic AF during oral anticoagulant treatment. 152 patients with chronic atrial fibrillation were classified according to presence of clinical risk factors, in high, moderate and low risk groups. Flasma levels of coagulation markers: prothrombin fragment 1+2, thrombin-antithrombin complexes, D-dimer and fibrinolytic markers: tissue plasminogen activator and plasminogen activator inhibitor antigen and activity were determined before and during anticoagulant treatment. Levels of coagulation markers were associated with age, female gender and heart failure. Levels of fibrinolytic markers correlated with female gender, hypertension, and diabetes, as well as with body mass index, levels of triglycerides and hDI. holesterol. Levels of coagulation markers were significantly suppressed during oral anticoagulant treatment and they were correlated with levels before treatment. hemostatic changes before treatment as well as during treatment increased proportionally with perceived thromotic risk with the highest levels of hemostatic markers in the high risk and the lowest levels in the low risk group. Despite adequate anticoagulant treatment during observation period of 4 years 20% patients suffered a major cardiovascular event. Beside heart failure, high levels of D-dimer during treatment and tissue plasminogen activator antigen levels were independently associated cardiovascular events. (Abstract truncated at 2000 characters) | |
| Descriptors | ATRIAL FIBRILLATION BLOOD COAGULATION DISORDERS ANTICOAGULANTS HEART FAILURE, CONGESTIVE ECHOCARDIOGRAPHY PROTHROMBIN ALTEPLASE PLASMINOGEN ACTIVATOR INHIBITOR 1 BODY MASS INDEX DIABETES MELLITUS TRIGLYCERIDES LIPOPROTEINS, HDL CHOLESTEROL AGE FACTORS SEX FACTORS |