Author/Editor		Beltram, Matej
Title		Primerjava učinkov Er:YAG laserja z različnimi načini delovanja na kožo periokularnega področja
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		2004
Volume		str. 57
Language		slo
Abstract		Background. One of the applications of the Er:YAG laser in oculoplastic surgery is laser skin resurfacing, at which denaturation of collagen in the dermis occurs. Contemporarily, an undesired ablation of the epidermis is produced, which possibly leads to harmful side effects. The goal of new skin resurfacing methods is to deliver energy into the dermis without epidermal injury. On the basis of theoretical models and animal tests such a goal can be achieved with the Er:YAG laser, too, but has yet to be proven on human skin in vivo. Purpose. To find out whether collagen denaturation with partial or full preservation of the epidermis can be achieved with the Er:YAG laser operating in a new, non-ablative mode. To compare the results of Er:YAG skin resurfacing using different modes. Patients and methods. The effects of Er:YAG laser skin resurfacing in different modes will be tested on redundant human lid skin of 30 patients with blepharochalasis immediately after, 1 week and 3 weeks following the procedure. We will assess epidermal injury and collagen denaturation in the dermis by histological examination. Results. We observed deep collagen denaturation at laser fluences over 1.25 J/cmz; epidermal damage was total at fluences over 1.75 J/cm2. At day 7 after laser treatment we observed a complete regeneration of the epidermal layer and a regeneration zone within the dermis with infiltration of mononuclear cells. At day 21 after laser treatment we observed collagen remodelling and fibroblast proliferation at tissue depths of up to 240 pm. Conclusions. We ascertained the safety and efficacy of Er:YAG laser skin resurfacing in the non-ablative mode. We noted a lesser degree of epidermal damage with comparable collagen denaturation and remodelling, compared to standard Er:YAG laser skin resurfacing treatment regimes. This makes the use of the non-ablative Er:YAG regime potentially feasible for clinical use.
Descriptors		SKIN LASER COAGULATION COLLAGEN EPIDERMIS INFLAMMATION BLEPHAROPTOSIS IMMUNOHISTOCHEMISTRY