Author/Editor		Hojs, Radovan; Hojs-Fabjan, Tanja; Pečovnik-Balon, Breda
Title		Atherosclerosis and risk factors in non-diabetic hemodialysis patients
Type		članek
Source		Dialysis Transplant
Vol. and No.		Letnik 33, št. 10
Publication year		2004
Volume		str. 624-33
Language		eng
Abstract		Background. Atherosclerosis is accelerated in hemodialysis (HD) patients. Little is known, however, about the impact of the major risk factors (smoking, hypertension, lipid abnormalities), calcium metabolism, or intact parathyroid hormone (iPTH) on asymptomatic atherosclerosis in these patients. Methods and materials. In this study involving 102 non-diabetic HD patients, B-mode ultrasonography was used to compare intima-media thickness (IMT) and plaque occurence in the carotid arteries of these patients with those of 30 control subjects without renal failure. Results. The IMT values were higher in the HD patients (0.75 mm vs. 0.62 mm), more patients had plaques (64% vs. 23%), and the number of plaques in the patients was greater. Correlation between IMT and age, but not with HD duration, was found. IMT values also correlated with total and LDL cholesterol. Plaque occurrence correlated with age, total and LDL cholesterol, triglycerides, and smoking. The number of plaques correlated with age and with total and LDL cholesterol. Multiple regression analysis revealed a relationship between IMT and age and with the presence of hypertension. A relationship between the number of plaques and age as well as with LDL cholesterol was found. Conclusion. The results indicate that non-diabetic HD patients show advanced atherosclerosis that is associated withage, lipid abnormalities, hypertension, and smoking, but not with calcium metabolism or iPTH.
Descriptors		HEMODIALYSIS ATHEROSCLEROSIS CAROTID ARTERIES TUNICA INTIMA TUNICA MEDIA ULTRASONOGRAPHY, DOPPLER, COLOR BLOOD PRESSURE SMOKING CHOLESTEROL LIPOPROTEINS CALCIUM PHOSPHORUS PARATHYROID HORMONES