Author/Editor     Kovačič, Uroš
Title     Kolateralno brstenje senzoričnih aksonov v živčno anastomozo konec s stranjo pri podgani
Type     monografija
Place     Ljubljana
Publisher     Medicinska fakulteta
Publication year     2004
Volume     str. 55
Language     slo
Abstract     Collateral sprouting is the process of multiple branching of an intact axon of an uninjured peripheral nerve, leading to the expansion of its innervation territory into a foreign territory abandoned by the injured nerve. Among the sensory axons, only the high-threshold afferents are involved in collateral sprouting in the skin of adult mammals. In addition, robust collateral sprouting of motor and sensory axons from an intact donor nerve trunk into the distal stump of a transected nerve which was sutured to the side of an uninjured donor nerve (end-to-side nerve anastomosis) has been convincingly demonstrated. It is not known whether the collateral sprouts of an uninjured donor sensory nerve, growing through the end-to-side nerve anastomosis, can functionally reinnervate the denervated skin of an injured nerve for a longer period of time after injury. In addition, it is also not known which type of sensory axons is capable of sprouting into the end-to-side nerve anastomosis. We used the model of end-to-side anastomosis between the distal stump of the transected peroneal nerve and the uninjured sural nerve in the rat. The sural nerve is very suitable for examination of collateral sprouting of sensory axons because more than 95% of its axons are sensory axons. Sixty-four albino rats were divided into four experimental groups, differing in the duration of the recovery period after performing the nerve anastomosis (8, 19, 25 or 36 weeks). The recovery of pain sensitivity in the skin of the instep was examined with the nociceptive skin pinch test. (Abstract truncated at 2000 characters)
Descriptors     PERONEAL NERVE
TIBIAL NERVE
SURAL NERVE
ANASTOMOSIS, SURGICAL
NERVE REGENERATION
NOCICEPTORS
ACTION POTENTIALS
NEURAL TUBE DEFECTS
AXONS
MICROSCOPY, ELECTRON
RATS, WISTAR