Author/Editor		Hei, Tom K; Filipič, Metka
Title		Role of oxidative damage in the genotoxicity of arsenic
Type		članek
Source		Free Radic Biol Med
Vol. and No.		Letnik 37, št. 5
Publication year		2004
Volume		str. 574-81
Language		eng
Abstract		Arsenic is a well-estab(ished human carcinogen and is ubiquitous in the environment. For decades, arsenic has been considered to be a nongenotoxic carcinogen because it is only weakly active or, more often, completely inactive in bacterial and mammalian cell mutation assays. In this review, evidence is presented that when assayed using model systems in which both intragenic and multilocus mutations can readily be detected, arsenic is, indeed, found to be a strong, dose-dependent mutagen which induces mostly multilocus deletions. Furchermore, the roles of reactive oxygen and reactive nitrogen species in mediating the genotoxic response are presented in a systematic and logical fashion in support of a working model. The data suggest that antioxidants may be a useful interventional treatment in reducing the deleterious effects of arsenic.
Descriptors		ARSENIC REACTIVE OXYGEN SPECIES MUTAGENICITY TESTS NITROGEN ANTIOXIDANTS FREE RADICALS ARSENITES