Author/Editor		Petrovec, M
Title		Vpliv različnega števila podkožno presajenih celic Ehrlichovega acsitesnega tumorja na razvoj tumorja
Translated title		The influence of different doses of subcutaneously transplanted Ehrlich ascites tumor cells on the development of the tumor
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 31, št. 1
Publication year		1992
Volume		str. 3-22
Language		slo
Abstract		The autors transplanted Ehrlich ascites tumor (EAT) cells to 90 inbred mice of CBA strain in order to investigate the role that sex of animal and dose of tumor cells play in the development and growth of the subcutaneus tumor, and to evaluate histologically the metastatic rate. They transplanted 13,6 x 10 6, 13,6 x 10 4, and 13,6 x 10 2 tumor cells, respectively, to three groups of animals. With the first two doses, transplantation succeeded in 100 per cent of cases, while with the last it was successful in 13,3 per cent of males and 40 per cent females. The dose of transplanted tumor cells was found to be inversely proportional to survival, and proportional to the subcutaneous tumor growth. With the same dose of transplanted tumor cells, a significantly shorter survival and a smaller tumor bulk were observed in females as compared to males. Histological examination of all viscera except the brain showed the highest metastatic rate in thd lung, kidney, suprarenal glands and pararenal lymph nodes. It was not influenced by the tumor dose or sex of the animal.
Descriptors		CARCINOMA, EHRLICH TUMOR SURVIVAL ANALYSIS NEOPLASM METASTASIS MICE, INBRED CBA ANIMALS, LABORATORY NEOPLASM TRANSPLANTATION SEX FACTORS